| 1 | BMC Psychiatry 2004 -1 4: 21 |
|---|---|
| PMID | 15296513 |
| 标题 | 兴奋性氨基酸转运蛋白2基因（SLC1A2）与精神分裂症中的多态性研究。 |
| Abstract | The glutamatergic dysfunction hypothesis ofschizophreniasuggests that genes involved in glutametergic transmission are candidates forschizophrenicsusceptibility genes. We have been performing systematic association studies ofschizophrenia和the glutamate receptor and transporter genes. In this study we report an association study of the excitatory amino acid transporter 2 gene,SLC1A2和schizophrenia。 我们基因分型100日语schizophrenics and 100 controls recruited from the Kyushu area for 11 single nucleotide polymorphism (SNP) markers distributed in theSLC1A2region using the direct sequencing and pyrosequencing methods, and examined allele, genotype and haplotype association withschizophrenia。The positive finding observed in the Kyushu samples was re-examined using 100 Japaneseschizophrenic从AICHI地区招募的S和100个控件。 We found significant differences in genotype and allele frequencies of SNP2 between cases and controls (P = 0.013 and 0.008, respectively). After Bonferroni corrections, the two significant differences disappeared. We tested haplotype associations for all possible combinations of SNP pairs. SNP2 showed significant haplotype associations with the disease (P = 9.4 x 10-5, P = 0.0052 with Bonferroni correction, at the lowest) in 8 combinations. Moreover, the significant haplotype association of SNP2-SNP7 was replicated in the cumulative analysis of our two sample sets. 我们得出结论，至少一个易感性基因座schizophreniais probably located within or nearbySLC1A2在日本人口中。 |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 2 | BMC Psychiatry 2004 -1 4: 21 |
| PMID | 15296513 |
| 标题 | 兴奋性氨基酸转运蛋白2基因（SLC1A2）与精神分裂症中的多态性研究。 |
| Abstract | The glutamatergic dysfunction hypothesis ofschizophreniasuggests that genes involved in glutametergic transmission are candidates forschizophrenicsusceptibility genes. We have been performing systematic association studies ofschizophrenia和the glutamate receptor and transporter genes. In this study we report an association study of the excitatory amino acid transporter 2 gene,SLC1A2和schizophrenia。 我们基因分型100日语schizophrenics and 100 controls recruited from the Kyushu area for 11 single nucleotide polymorphism (SNP) markers distributed in theSLC1A2region using the direct sequencing and pyrosequencing methods, and examined allele, genotype and haplotype association withschizophrenia。The positive finding observed in the Kyushu samples was re-examined using 100 Japaneseschizophrenic从AICHI地区招募的S和100个控件。 We found significant differences in genotype and allele frequencies of SNP2 between cases and controls (P = 0.013 and 0.008, respectively). After Bonferroni corrections, the two significant differences disappeared. We tested haplotype associations for all possible combinations of SNP pairs. SNP2 showed significant haplotype associations with the disease (P = 9.4 x 10-5, P = 0.0052 with Bonferroni correction, at the lowest) in 8 combinations. Moreover, the significant haplotype association of SNP2-SNP7 was replicated in the cumulative analysis of our two sample sets. 我们得出结论，至少一个易感性基因座schizophreniais probably located within or nearbySLC1A2在日本人口中。 |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 3 | BMC Psychiatry 2004 -1 4: 21 |
| PMID | 15296513 |
| 标题 | 兴奋性氨基酸转运蛋白2基因（SLC1A2）与精神分裂症中的多态性研究。 |
| Abstract | The glutamatergic dysfunction hypothesis ofschizophreniasuggests that genes involved in glutametergic transmission are candidates forschizophrenicsusceptibility genes. We have been performing systematic association studies ofschizophrenia和the glutamate receptor and transporter genes. In this study we report an association study of the excitatory amino acid transporter 2 gene,SLC1A2和schizophrenia。 我们基因分型100日语schizophrenics and 100 controls recruited from the Kyushu area for 11 single nucleotide polymorphism (SNP) markers distributed in theSLC1A2region using the direct sequencing and pyrosequencing methods, and examined allele, genotype and haplotype association withschizophrenia。The positive finding observed in the Kyushu samples was re-examined using 100 Japaneseschizophrenic从AICHI地区招募的S和100个控件。 We found significant differences in genotype and allele frequencies of SNP2 between cases and controls (P = 0.013 and 0.008, respectively). After Bonferroni corrections, the two significant differences disappeared. We tested haplotype associations for all possible combinations of SNP pairs. SNP2 showed significant haplotype associations with the disease (P = 9.4 x 10-5, P = 0.0052 with Bonferroni correction, at the lowest) in 8 combinations. Moreover, the significant haplotype association of SNP2-SNP7 was replicated in the cumulative analysis of our two sample sets. 我们得出结论，至少一个易感性基因座schizophreniais probably located within or nearbySLC1A2在日本人口中。 |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 4 | Cell. Physiol. Biochem. 2007 -1 20: 687-702 |
| PMID | 17982252 |
| 标题 | Molecular mechanisms of schizophrenia. |
| Abstract | schizophreniais a complex disorder, where family, twin and adoption studies have been demonstrating a high heritability of the disease and that this disease is not simply defined by several major genes but rather evolves from addition or potentiation of a specific cluster of genes, which subsequently determines the genetic vulnerability of an individual. Linkage and association studies suggest that a genetic vulnerablility, is not forcefully leading to the disease since triggering factors and environmental influences, i.e. birth complications, drug abuse, urban background or time of birth have been identified. This has lead to the assumption thatschizophrenia不仅是基因定义静态障碍but a dynamic process leading to dysregulation of multiple pathways. There are several different hypothesis based on several facets of the disease, some of them due to the relatively well-known mechanisms of therapeutic agents. The most widely considered neurodevelopmental hypothesis ofschizophrenia整合环境影响和致病基因。多巴胺假说schizophrenia基于以下事实：所有常见治疗涉及抗多巴胺能机制和基因，例如DRD2，DRD3，DARPP-32，BDNF或COMT与多巴胺能系统的功能密切相关。谷氨酸能的假设schizophrenialead recently to a first successful mGlu2/3 receptor agonistic drug and is underpinned by significant findings in genes regulating the glutamatergic system (SLC1A6,SLC1A2grin1，grin2a，gria1，nrg1，erbb4，dtnbp1，daao，g72/30，grm3）。相应地，已经提出了GABA调节该疾病的病理生理学，而Gabra1，Gabrp，Gabra6和Reelin等基因的参与表示。此外，据报道有几种涉及免疫，信号传导和网络缺陷的基因参与该疾病，即DISC1，RGS4，PODH，DGCR6，ZDHHC8，DGCR2，DGCR2，AKT，AKT，CREB，CREB，CREB，IL-1B，IL-1B，IL-1RN，IL-1RN，IL-10，IL-10，IL-10，IL-10，，IL-10，，IL-10，，IL-10，，IL-10，，，IL-1B。然而，分子发现表明受体，激酶，蛋白质和激素之间的复杂相互作用参与schizophrenia。在一个统一的假设中，不同的级联合并成另一个级联，最终导致症状的发展schizophrenicdisorders. |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 5 | Cell. Physiol. Biochem. 2007 -1 20: 687-702 |
| PMID | 17982252 |
| 标题 | Molecular mechanisms of schizophrenia. |
| Abstract | schizophreniais a complex disorder, where family, twin and adoption studies have been demonstrating a high heritability of the disease and that this disease is not simply defined by several major genes but rather evolves from addition or potentiation of a specific cluster of genes, which subsequently determines the genetic vulnerability of an individual. Linkage and association studies suggest that a genetic vulnerablility, is not forcefully leading to the disease since triggering factors and environmental influences, i.e. birth complications, drug abuse, urban background or time of birth have been identified. This has lead to the assumption thatschizophrenia不仅是基因定义静态障碍but a dynamic process leading to dysregulation of multiple pathways. There are several different hypothesis based on several facets of the disease, some of them due to the relatively well-known mechanisms of therapeutic agents. The most widely considered neurodevelopmental hypothesis ofschizophrenia整合环境影响和致病基因。多巴胺假说schizophrenia基于以下事实：所有常见治疗涉及抗多巴胺能机制和基因，例如DRD2，DRD3，DARPP-32，BDNF或COMT与多巴胺能系统的功能密切相关。谷氨酸能的假设schizophrenialead recently to a first successful mGlu2/3 receptor agonistic drug and is underpinned by significant findings in genes regulating the glutamatergic system (SLC1A6,SLC1A2grin1，grin2a，gria1，nrg1，erbb4，dtnbp1，daao，g72/30，grm3）。相应地，已经提出了GABA调节该疾病的病理生理学，而Gabra1，Gabrp，Gabra6和Reelin等基因的参与表示。此外，据报道有几种涉及免疫，信号传导和网络缺陷的基因参与该疾病，即DISC1，RGS4，PODH，DGCR6，ZDHHC8，DGCR2，DGCR2，AKT，AKT，CREB，CREB，CREB，IL-1B，IL-1B，IL-1RN，IL-1RN，IL-10，IL-10，IL-10，IL-10，，IL-10，，IL-10，，IL-10，，IL-10，，，IL-1B。然而，分子发现表明受体，激酶，蛋白质和激素之间的复杂相互作用参与schizophrenia。在一个统一的假设中，不同的级联合并成另一个级联，最终导致症状的发展schizophrenicdisorders. |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 6 | 生物。精神病学2008年7月64日：89-97 |
| PMID | 18191109 |
| 标题 | Shared gene expression alterations in schizophrenia and bipolar disorder. |
| Abstract | schizophrenia双相情感障碍共同影响了大约2.5％的世界人口，其病因被认为涉及多种遗传变异和环境影响。大脑中基因表达模式的分析可能为每种疾病提供特征性的特征。 RNA samples from the dorsolateral prefrontal cortex (Brodmann area 46) consisting of individuals withschizophrenia(SZ), bipolar disorder (BPD), and control subjects were tested on the Codelink Human 20K Bioarray platform. Selected transcripts were validated by quantitative real-time polymerase chain reaction (PCR). The strong effects of age, gender, and pH in the analysis of differential gene expression were controlled by analysis of covariance (ANCOVA). Criteria for differential gene expression were 1) a gene was significantly dysregulated in both BPD and SZ compared with control subjects and 2) significant in ANCOVA analysis with samples that have a pH above the median of the sample. A list of 78 candidate genes passed these two criteria in BPD and SZ and was overrepresented for functional categories of nervous system development, immune system development and response, and cell death. Five dysregulated genes were confirmed with quantitative Q-PCR in both BPD and SZ. Three genes were highly enriched in brain expression (AGXT2L1,SLC1A2，和tu3a）。Agxt2L1在对照对象与BPD和SZ中的表达的分布非常重要（Fisher的精确检验，p <10（-06））。 These results suggest a partially shared molecular profile for both disorders and offer a window into discovery of common pathophysiology that might lead to core treatments. |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 7 | Neurosci。Lett。2009年10月463日：223-7 |
| PMID | 19660525 |
| 标题 | 没有遗传SLC1A2基因之间的联系和Japanese patients with schizophrenia. |
| Abstract | Glutamatergic dysfunction may be a pathophysiological feature in the brains ofschizophrenic病人。除谷氨酸受体外，兴奋性氨基酸转运蛋白（EAATS）也受到了很多关注，因为它们直接通过将过量的谷氨酸排除在突触left中，直接影响谷氨酸能神经传递。其中，EAAT2（也称为Solute Carrier家族1，成员2；SLC1A2) has been widely studied inschizophreniapathophysiology. During the last decade, we reported significant decreases in EAAT2 mRNA expression in the prefrontal cortex and parahippocampal gyrus in postmortemschizophrenicbrains. Previously, a haplotype association betweenSLC1A2和日本患者schizophreniawas reported. In this study, we reinvestigated the association betweenSLC1A2和schizophreniaby performing a case-control association study with twice as many subjects (401 cases and 407 controls) as compared to a previous study, and especially focused on the region where a previous association withschizophreniahad been shown. Our current results failed to show any significant association withschizophrenia在单个单核苷酸多态性（SNP）中，基于两种和三SNP的单倍型或可能的成对单倍型分析。SCL1A2似乎不是遗传危险因素schizophrenia。 |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 8 | Neurosci。Lett。2009年10月463日：223-7 |
| PMID | 19660525 |
| 标题 | 没有遗传SLC1A2基因之间的联系和Japanese patients with schizophrenia. |
| Abstract | Glutamatergic dysfunction may be a pathophysiological feature in the brains ofschizophrenic病人。除谷氨酸受体外，兴奋性氨基酸转运蛋白（EAATS）也受到了很多关注，因为它们直接通过将过量的谷氨酸排除在突触left中，直接影响谷氨酸能神经传递。其中，EAAT2（也称为Solute Carrier家族1，成员2；SLC1A2) has been widely studied inschizophreniapathophysiology. During the last decade, we reported significant decreases in EAAT2 mRNA expression in the prefrontal cortex and parahippocampal gyrus in postmortemschizophrenicbrains. Previously, a haplotype association betweenSLC1A2和日本患者schizophreniawas reported. In this study, we reinvestigated the association betweenSLC1A2和schizophreniaby performing a case-control association study with twice as many subjects (401 cases and 407 controls) as compared to a previous study, and especially focused on the region where a previous association withschizophreniahad been shown. Our current results failed to show any significant association withschizophrenia在单个单核苷酸多态性（SNP）中，基于两种和三SNP的单倍型或可能的成对单倍型分析。SCL1A2似乎不是遗传危险因素schizophrenia。 |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 9 | Front Behav Neurosci 2010 -1 4：32 |
| PMID | 20589092 |
| 标题 | Ethanol and phencyclidine interact with respect to nucleus accumbens dopamine release: differential effects of administration order and pretreatment protocol. |
| Abstract | 执行功能障碍是酒精依赖人的常见症状。苯基肽（PCP）注射会在动物的前额叶皮层中诱导功能障碍，但对PCP如何影响对乙醇的反应知之甚少。使用雄性Wistar大鼠体内微透析技术，我们研究了5 mg/kg PCP的全身注射如何影响局部输注300 mM乙醇对伏抗核的局部输注引起的多巴胺释放。在乙醇完全阻断乙醇诱导的多巴胺释放之前，PCP给出了60分钟。但是，当乙醇在PCP前60分钟之前给药时，两种药物诱导多巴胺释放，PCP的作用受到乙醇的增强（增长180％vs 150％）。为了测试前额叶皮层功能障碍在乙醇增强中的作用，根据先前使用的“ PFC功能低下方案”，将动物用2.58 mg/kg PCP预处理5天。但是，与盐水处理的对照相比，这并没有改变对PCP或乙醇的相对反应。QPCR说明，这种低PCP剂量并未显着改变葡萄糖转运蛋白GLUT1（SLC2A1）或GLUT3（SLC2A3），单羧酸盐转运蛋白MCT2（SLC16A7），谷氨酸转运蛋白转运蛋白转运蛋白的表达SLC1A2）或GLAST（SLC1A3），即直接的早期基因弧（ARG3.1）或GABA能神经元标记GAT-1（SLC6A1）和白蛋白蛋白。因此，我们得出的结论是，剂量为2.58 mg/kg 5天的PCP不会诱导Wistar大鼠的功能障碍。但是，PCP和乙醇确实具有重叠的作用机制，这些药物会根据给药顺序差异地影响中唇胶质性多巴胺能的传播。 |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 10 | Behav. Brain Res. 2013 Nov 257: 118-28 |
| PMID | 24076151 |
| 标题 | 前脑基因表达预测雄性大鼠分离饲养后感觉运动门控的缺陷。 |
| Abstract | 与社会内部的（SH）大鼠相比，成年孤立性（IR）大鼠表现出与schizophrenia(SZ), including reduced prepulse inhibition (PPI) of startle. PPI is normally regulated by the medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). We assessed PPI, auditory-evoked local field potentials (LFPs) and expression of seven PPI- and SZ-related genes in the mPFC and NAC, in IR and SH rats. Buffalo (BUF) rats were raised in same-sex groups of 2-3 (SH) or in isolation (IR). PPI was measured early (d53) and later in adulthood (d74); LFPs were measured approximately on d66. Brains were processed for RT-PCR measures of mPFC and NAC expression of Comt, Erbb4, Grid2, Ncam1,SLC1A2，NRG1和Reln。雄性IR大鼠表现出PPI缺陷，最明显的D53；在两个测试日，男性和雌性IR大鼠的惊吓幅度都显着升高。IR没有显着改变基因表达水平。PPI水平（D53）与几个基因的MPFC表达呈正相关，并且与男性IR中的NAC表达负相关，但在男性IR中，但与SH大鼠无关。晚期（P90）LFP振幅与雄性大鼠的6/7 MPFC基因的表达水平显着相关，而与饲养无关。IR破坏了雄性BUF大鼠的早期成年PPI后，MPFC中PPI和SZ相关基因的表达水平与PPI正相关，而NAC的水平与PPI负相关。这些结果支持了特定基因行为关系的模型，使早期经验对SZ相关的行为和神经生理学标记的影响。 |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 11 | Neuropharmacology 2013 Dec 75: 38-46 |
| PMID | 23810830 |
| 标题 | Coupling of gene expression in medial prefrontal cortex and nucleus accumbens after neonatal ventral hippocampal lesions accompanies deficits in sensorimotor gating and auditory processing in rats. |
| Abstract | 新生儿腹侧海马病变（NVHL）后，成年大鼠表现出与与schizophrenia, including reduced prepulse inhibition (PPI) of acoustic startle and impaired sensory processing. In intact rats, the regulation of PPI by the ventral hippocampus (VH) is mediated via interactions with medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). We assessed PPI, auditory-evoked responses and expression of 7schizophrenia-related genes in mPFC and NAC, in adult rats after sham- or real NVHLs. 雄性近交牛buffo（buf）大鼠幼崽（D7; n = 36）接受了VH中的载体或伊布烯酸输注。分别在D56和D66上测量了PPI和听觉诱发的齿状回局部场电位（LFP）。处理MPFC和NAC COMT，ERBB4，GRID2，NCAM1，SLC1A2，NRG1和Reln。 NVHL大鼠在PPI（P = 0.005）和LFP（P <0.015）中表现出明显缺陷，与病变大小成正比。SHAM与NVHL大鼠在MPFC或NAC中的基因表达水平没有差异。正如我们先前报道的那样，多个基因表达水平高度相关 - （平均r's？0.5），但跨脑区域不相关（平均r's？0）。但是，对于三个基因 - comt，SLC1A2NCAM1 - NVHLS后，表达水平在MPFC和NAC上显着相关或“耦合”（分别为P的<0.03、0.002和0.05），而“耦合”程度随VH病变大小而增加。 在破坏PPI和听觉处理的NVHL之后，特定的基因表达水平表明MPFC和NAC的功能偶联异常。NVHL之后的VH-MPFC-NAC网络功能障碍的这种模型可能对理解PPI和相关感觉处理缺陷的神经基础有影响schizophrenia病人。 |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 12 | Am. J. Med. Genet. B Neuropsychiatr. Genet. 2014 Dec 165B: 635-46 |
| PMID | 25209194 |
| 标题 | Synergistic association of PI4KA and GRM3 genetic polymorphisms with poor antipsychotic response in south Indian schizophrenia patients with low severity of illness. |
| Abstract | Literature indicates key role of glutamatergic pathway genes in antipsychotic response amongschizophrenia病人。However, molecular basis of their underlying role in antipsychotic response remained unexplained. Thus, to unravel their molecular underpinnings, we sought to investigate interactions amongst GRM3, SLC1A1,SLC1A2，SLC1A3，SLC1A4基因多态性在南印度的药物反应schizophrenia病人。We genotyped 48 SNPs from these genes in 423schizophrenia患者分层为疾病组的低严重程度。检查了相关SNP的SNP和单倍型组合是否与抗精神病药反应相关。多因素 - 差异性还用来探索这些SNP中的基因 - 基因相互作用和先前研究的基因（BDNF，RGS4，SLC6A3，PI4KA和PIP4K2A）的53个SNP。单个SNP和单倍型分析显示，与药物反应无关，而与疾病的严重程度无关。基因 - 基因相互作用分析产生了有希望的潜在客户，包括PI4KA_RS165854和GRM3_RS1468412多态性和不完整的抗精神病药反应之间观察到的协同作用schizophreniapatients with low severity of illness (OR = 12.4; 95%CI = 3.69-41.69). Further, this interaction was also observed in atypical monotherapy (n = 355) and risperidone (n = 260) treatment subgroups (OR = 11.21; 95%CI = 3.30-38.12 and OR = 13.5; 95%CI = 3.03-121.61 respectively). PI4KA is known to be involved in the biosynthesis of phosphatidylinositol-4, 5-bisphosphate which regulates exocytotic fusion of synaptic vesicles (glutamate, dopamine) with the plasma membrane and regulates duration of signal transduction of GPCRs. Whereas GRM3 regulates glutamate and dopamine transmission. Present findings indicate that PI4KA and GRM3 polymorphisms have potential to jointly modulate antipsychotic response. These results warrant additional replication studies to shed further light on these interactions. |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 13 | Schizophr. Res. 2015 Dec 169: 128-34 |
| PMID | 26459047 |
| 标题 | SLC1A2和精神分裂症中的常见变异：精神分裂症和健康个体患者的关联和认知功能。 |
| Abstract | SLC1A2is reported to be responsible for the majority of glutamate uptake, which has a crucial role in neural development and synaptic plasticity, and a disturbance in glutamatergic transmission has been suggested to be involved in the pathophysiology ofschizophrenia(SCZ) and cognition. To evaluate the relationship of common variants withinSLC1A2在汉族中，有28个标签SNP在发现阶段进行了基因分型，其中包括1117例和2289个对照。在复制阶段，具有2128例病例和3865个对照的复制阶段，对相关的标记有显着相关的标记。在两个数据集中，RS4354668 SNP与SCZ均显着相关，并且在两阶段进行插补和单倍型关联分析的研究中也观察到了类似的模式。此外，在处理患者和对照组中威斯康星州卡分类测试的持续性误差时，观察到RS4354668 SNP与认知之间的显着关联。我们的结果提供了支持证据的影响SLC1A2on the etiology of SCZ, suggesting that genetic variation (rs4354668 and its haplotypes) inSLC1A2may be involved in impaired executive function, which adds to the current body of knowledge regarding the risk of SCZ and the impairment of cognitive performance. |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 14 | 欧元。J. Hum。基因。2015年9月23日：1200-6 |
| PMID | 25406999 |
| 标题 | 谷氨酸受体基因SLC1A2罕见变异与对躁郁症和精神分裂症的敏感性的关联。 |
| Abstract | TheSLC1A2gene encodes the excitatory amino acid transporter 2 (EAAT2). Glutamate is the major mediator of excitatory neurotransmission and EAAT2 is responsible for clearing the neurotransmitter from the synaptic cleft. Genetic variation inSLC1A2已与一系列神经和神经精神疾病有关schizophrenia（SZ），自闭症和双相情感障碍（BD）的核心表型。编码和推定的监管区域SLC1A2gene were screened for variants using high resolution melting or sequenced in 1099 or in 32 BD subjects. Thirty-two variants were detected in theSLC1A2基因。在1099 BD和1095个对照样品中选择了15种潜在的病因变异物进行基因分型。在患有SZ的630名参与者中，还对五种变化的变体进行了基因分型。没有发现任何变体与BD或SZ或两种疾病组合有关。然而，两个经常性的错义变体（RS145827578：g> a，p。（g6s）; rs199599866：g> a，p。（r31q））和一个经常性的5'-非转移区域（utr）变体（ss825556788888885：g>> t）仅在情况下检测到。对仅经常性错义变体和仅案例错义和5'-UTR变体的合并分析显示出与综合疾病相关的名义证据（Fisher's P = 0.019和0.0076）。这些发现本质上是探索性的，并且在较大的队列中等待复制，但是，它们提供了有趣的证据，表明潜在的功能性稀有变体SLC1A2gene may confer susceptibility to psychotic disorders. |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |
| 15 | Behav. Brain Res. 2016 Apr 302: 115-21 |
| PMID | 26778785 |
| 标题 | 在大鼠的隔离范围内，感觉运动门控缺陷是可以遗传的。 |
| Abstract | Early life experience is a key etiological factor of neuropsychiatric dysfunctions and is associated with developmental origins. Impaired prepulse inhibition (PPI) following an acoustic startle response is acknowledged as a cardinal characteristic in socially deprived weanling rats, which has been employed to investigate the underlying mechanisms of sensorimotor gating abnormalities in certain mental disorders, includingschizophrenia。由于PPI受损是产后故障，因此检查是否可以传递给下一代很有趣。自从断奶以来，育成的（IR）大鼠已被社会剥夺，与社会饲养大鼠交配。接下来，在正常的社会环境中饲养了红外大鼠的后代。运动，PPI，单胺和基因schizophrenia-relevant brain areas [medial prefrontal cortex (mPFC) and hippocampus] were later measured. To this end, we observed that the next generation of IR offspring rats appeared with impaired PPI in which the PPI deficit can be observed as early as three weeks after birth. The third generation also exhibited lower levels of dopamine and serotonin in the mPFC and hippocampus; however, higher levels of both monoamines were measured in the striatum. Finally,SLC1A2在第三代雄性大鼠的MPFC中更高表达。本研究证明了IR诱导特征的跨代遗传，并可能有助于阐明基本的病因学schizophrenia。 |
| SCZ关键字 | schizophrenia, schizophrenic, schizophrenics |