| 1 | BMB Rep 2010 Sep 43: 593-8 |
|---|---|
| PMID | 20846490 |
| Title | 多巴胺和谷氨酸神经传递在四氢无菌缺乏SPR - / - 小鼠中的改变：与精神分裂症相关。 |
| 抽象的 | 四氢无生物蛋白酶（BH4）是负责合成和释放单胺神经递质（包括多巴胺（DA）和5-羟色胺（5-HT）以及谷氨酸（GLU）（GLU）的合成和释放的酶。最近已经报道了BH4水平的缺陷和BH活性降低（4）相关酶精神分裂症。因此，BH（4）调节的生化级联反应可能会改变DA，5-HT和GLU神经传递，从而改变包括不同神经精神疾病的病理生理学，包括不同的神经精神疾病精神分裂症。The development of a novel strain of mutant mice that is deficient in BH(4) by knocking out the expression of a functional sepiapterin reductase gene (spr-/-) has added new insights into the potential role of BH(4) in the pathophysiology and improved treatment of精神分裂症。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 2 | Clin Psychopharmacol Neurosci 2011 Dec 9: 117-21 |
| PMID | 23430042 |
| Title | DSM-IV诊断的诊断稳定性：对韩国患者的重度抑郁症，双相情感障碍和精神分裂症的检查。 |
| 抽象的 | We examined the stability of diagnoses defined by the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) (major depressive disorder [MDD], bipolar I disorder [BID], and精神分裂症[[spr]) by means of retrospective reviews of medical records. 根据两名精神科医生，符合上述疾病的DSM-IV标准的患者的数据纳入了至少2年的时间。我们审查了医疗记录，并将指数入院时给出的诊断与出院后2年的每6个月进行的评估进行了比较，以确定诊断稳定性。 共有138例MDD患者，56例出价患者和107例患者sprwho were followed for 2 years were included in the final analyses. The data showed that 84.8% of the sample retained their initial diagnosis of MDD during the first year; this figure decreased to 79.0% during the second year. During the first year, 93.5% retained their initial diagnosis of BID, and this figure decreased to 89.3% during the second year; 86.8% and 86.9% retained their diagnosis ofsprduring the first and second years, respectively. This study showed the instability of three major DSM-IV diagnoses among Korean patients. Additionally, the results demonstrated that accurate diagnosis using the current diagnostic system requires longitudinal observation. |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 3 | 心理生理学2011年10月48日：1323-32 |
| PMID | 21496056 |
| Title | Nonlinear relationship between electrodermal activity and heart rate variability in patients with acute schizophrenia. |
| 抽象的 | We investigated to what degree tonic skin conductance levels (SCL) and cardiac autonomic dysfunction are interrelated in精神分裂症。Heart rate variability (HRV) and SCL were simultaneously assessed in 18 unmedicated patients and 18 controls matched for age, sex, weight, and smoking habits. For comparison to prior studies, phasic sympathetic skin responses (spr）还记录了。与对照组相比，患者延长了sprlatency and reducedspramplitude with a right-greater-than-left asymmetry, which was inversely correlated with positive symptoms. An autonomic imbalance was reflected in linear and nonlinear measures of HRV and increased SCL. Patients showed a stronger nonlinear association between SCL and heart rate than controls. HRV and SCL findings were strongly affected by group differences in breathing rate. Stronger HRV-SCL coupling in patients may suggest augmented sympathetic modulation in精神分裂症。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 4 | J.神经。精神。dis。2011年2月199日：106-10 |
| PMID | 21278539 |
| Title | 应对超高风险和精神分裂症患者的精神病理学的应对策略及其与精神病学的关系。 |
| 抽象的 | This study's aim was to investigate coping strategies and their relationship to symptoms in people at ultra high risk (UHR) for psychosis compared with recent-onset精神分裂症(spr) and healthy controls. Thirty-three UHR participants, 22sprpatients, and 33 healthy controls completed the Ways of Coping Questionnaire and other clinical measures. People at UHR for psychosis showed significantly more reliance on tension-reduction and less reliance on problem-focused coping than healthy controls. Thesprgroup showed more reliance on tension-reduction coping than healthy controls at a trend level. Maladaptive coping patterns were associated with higher levels of negative symptoms, depression, and anxiety in both the UHR andsprgroups. These findings suggest that maladaptive coping strategies might have already emerged in the (putative) prodromal stage and could influence symptom severities. |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 5 | 经验。摩尔。医学2012年2月44日：121-9 |
| PMID | 22089088 |
| Title | EGR2基因与韩国双相情感障碍的遗传关联。 |
| 抽象的 | The early growth response gene 2 (EGR2) is located at chromosome 10q21, one of the susceptibility loci in bipolar disorder (BD). EGR2 is involved in cognitive function, myelination, and signal transduction related to neuregulin-ErbB receptor, Bcl-2 family proteins, and brain-derived neurotrophic factor. This study investigated the genetic association of the EGR2 gene with BD and精神分裂症(spr） 在韩国。在946名受试者中（350个健康对照，352例BD患者，244例spr), nine single nucleotide polymorphisms (SNPs) in the EGR2 gene region were genotyped. Five SNPs showed nominally significant allelic associations with BD (rs2295814, rs61865882, rs10995315, rs2297488, and rs2297489), and the positive associations of all except rs2297488 remained significant after multiple testing correction. Linkage disequilibrium structure analysis revealed two haplotype blocks. Among the common identified haplotypes (frequency > 5%), 'T-G-A-C-T (block 1)' and 'A-A-G-C (block 2)' haplotypes were over-represented, while 'C-G-G-T-T (block 1)' haplotype was under-represented in BD. In contrast, no significant associations were found withspr。尽管需要进行较大样本量或独立复制的扩展分析，但这些发现表明EGR2与BD的遗传关联。结合EGR2的合理生物学功能，EGR2基因是BD中可能的敏感性基因。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 6 | Glycobiology 2015 Oct 25: 1112-24 |
| PMID | 26163659 |
| Title | 多氨酸对FGF2和ProbDNF/BDNF蛋白水解裂解的保护作用。 |
| 抽象的 | Polysialic酸(polySia)是一个年代的线性聚合物ialic acid that modifies neural cell adhesion molecule (NCAM) in the vertebrate brain. PolySia is a large and exclusive molecule that functions as a negative regulator of cell-cell interactions. Recently, we demonstrated that polySia can specifically bind fibroblast growth factor 2 (FGF2) and BDNF; however, the protective effects of polySia on the proteolytic cleavage of these proteins remain unknown, although heparin/heparan sulfate has been shown to impair the cleavage of FGF2 by trypsin. Here, we analyzed the protective effects of polySia on the proteolytic cleavage of FGF2 and proBDNF/BDNF. We found that polySia protected intact FGF2 from tryptic activity via the specific binding of extended polySia chains on NCAM to FGF2. Oligo/polySia also functioned to impair the processing of proBDNF by plasmin via binding of oligo/polySia chains on NCAM. In addition, the polySia structure synthesized by mutated polysialyltransferase, ST8SIA2/STX(SNP7), which was previously identified from a精神分裂症patient, was impaired for these functions compared with polySia produced by normal ST8SIA2. Taken together, these data suggest that the protective effects of polySia toward FGF2 and proBDNF may be involved in the regulation of the concentrations of these neurologically active molecules. |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 7 | Neuropsychiatr dis Treat 2015 -1 11：2793-9 |
| PMID | 26604763 |
| Title | 在汉族人群中，链球菌还原酶基因启动子多态性与精神分裂症的协会研究。 |
| 抽象的 | Sepiapterin reductase participates in the biosynthesis of tetrahydrobiopterin, which plays very important roles in the pathogenesis of精神分裂症via dysregulation of neurotransmitter systems. Here, two single nucleotide polymorphisms (rs1876487 and rs2421095) in the promoter region ofspr在941中进行了基因分型精神分裂症patients and 944 controls in a Han Chinese population using the SNaPshot technique. No significant differences were found in the distribution of alleles or genotypes of the two single nucleotide polymorphisms (SNPs) between精神分裂症patients and controls (all P>0.05). Likewise, no haplotype was found to be associated with精神分裂症。然而，性别分层的分析表明，A-A-A和A-A（RS2421095-RS1876487）单倍型的A等位基因的频率均显着差异精神分裂症and controls in females (P=0.040 and P=0.033, respectively), but not in males. Additionally, luciferase reporter gene assays revealed that the A-A haplotype had significantly highersprtranscriptional activity compared with the A-C haplotype in SH-SY5Y cells. Our data indicate that the two SNPs do not influence the risk of精神分裂症when using the total sample, but the A allele of rs1876487 and the A-A haplotype may contribute to protective roles for精神分裂症在女性。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 8 | Neuropsychiatr dis Treat 2015 -1 11：2793-9 |
| PMID | 26604763 |
| Title | 在汉族人群中，链球菌还原酶基因启动子多态性与精神分裂症的协会研究。 |
| 抽象的 | Sepiapterin reductase participates in the biosynthesis of tetrahydrobiopterin, which plays very important roles in the pathogenesis of精神分裂症via dysregulation of neurotransmitter systems. Here, two single nucleotide polymorphisms (rs1876487 and rs2421095) in the promoter region ofspr在941中进行了基因分型精神分裂症patients and 944 controls in a Han Chinese population using the SNaPshot technique. No significant differences were found in the distribution of alleles or genotypes of the two single nucleotide polymorphisms (SNPs) between精神分裂症patients and controls (all P>0.05). Likewise, no haplotype was found to be associated with精神分裂症。然而，性别分层的分析表明，A-A-A和A-A（RS2421095-RS1876487）单倍型的A等位基因的频率均显着差异精神分裂症and controls in females (P=0.040 and P=0.033, respectively), but not in males. Additionally, luciferase reporter gene assays revealed that the A-A haplotype had significantly highersprtranscriptional activity compared with the A-C haplotype in SH-SY5Y cells. Our data indicate that the two SNPs do not influence the risk of精神分裂症when using the total sample, but the A allele of rs1876487 and the A-A haplotype may contribute to protective roles for精神分裂症在女性。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 9 | 精神病学Res 2015 Jul 228：95-9 |
| PMID | 25977072 |
| Title | 治疗前后精神分裂症患者血浆血管内皮生长因子水平的改变。 |
| 抽象的 | Vascular endothelial growth factor (VEGF), a potent angiogenetic factor, is a known neurotrophic factor. In this study, we examined plasma levels of VEGF in 50 patients with精神分裂症(spr）和50名健康对照受试者。我们还探索了6周治疗抗精神病药后血浆VEGF水平的任何变化精神分裂症。所有主题与精神分裂症were either medication-na�ve or medication-free for at least 4 weeks before assessment. Plasma VEGF levels in all subjects were significantly correlated with smoking duration, which was considered to be a significant covariate. Pre-treatment plasma VEGF levels in patients with精神分裂症were significantly lower than those in healthy controls. Post-treatment VEGF levels were significantly increased in patients with精神分裂症。Plasma VEGF levels in patients with精神分裂症在基线或6周治疗结束时，与正面和负综合征量表（PANSS）的总分数或子量表分数没有显着相关性。总之，我们的发现表明，治疗前血浆VEGF水平较低精神分裂症并且他们的VEGF水平在治疗后增加。因此，VEGF在改善中可能具有神经保护作用精神分裂症或抗精神病药的治疗作用。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 10 | Neurosci. Lett. 2015 Mar 589: 126-31 |
| PMID | 25595562 |
| Title | 定量脑电图在未经药物的精神分裂症中的诊断效用。 |
| 抽象的 | The aim of the current study was to evaluate the quantitative electroencephalography (QEEG) characteristics of patients with un-medicated精神分裂症(spr) and to investigate the diagnostic utility of QEEG in assessing such patients during resting conditions. The subjects included 90 patients with精神分裂症and 90 normal controls. Spectral analysis was performed on the absolute power of all of the electrodes across five frequency bands following artifact removal. We conducted a repeated-measures ANOVA to examine group differences within the five frequency bands across several brain regions and receiver operator characteristic (ROC) analyses to examine the discrimination ability of each frequency band. Compared with controls, patients with精神分裂症showed increased delta and theta activity and decreased alpha 2 activity, particularly in the frontocentral area. There were no significant differences in the alpha 1 and beta activity. The ROC analysis performed on the delta frequency band generated the best result, with an overall classification accuracy of 62.2%. The results of this study confirmed the characteristics of the QEEG power in un-medicated精神分裂症患者与正常对照组相比。这些发现表明，休息的脑电图测试可以是评估患者的支持工具精神分裂症。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 11 | IEEE跨神经系统康复ENG 2016 APR -1：-1 |
| PMID | 27071182 |
| Title | Abnormal Neural Oscillations in Schizophrenia Assessed by Spectral Power Ratio of MEG during Word Processing. |
| 抽象的 | This study investigated spectral power of neural oscillations associated with word processing in精神分裂症。Magnetoencephalography (MEG) data were acquired from 12精神分裂症在视觉文字处理任务中，患者和10个健康对照。两个光谱功率比（spr）功能集：从5个频带中的MEG数据，4个时间处理的Word Processing windows以及在整个头部覆盖的位置，从MEG数据中提取了带功率比（BPR）和窗口功率比（WPR）。采用基于群集的非参数置换测试来识别sprS显示出显着的组间差异。然后采用基于机器学习的功能选择和分类技术来选择重要的最佳组合spr功能，区分精神分裂症patients from healthy controls. We identified 3 BPR clusters and 3 WPR clusters that show significant oscillation power difference between groups. These include the theta/delta, alpha/delta and beta/delta BPRs during base-to-encode and encode time windows, and the beta band WPR from base to encode and from encode to post windows. Based on 2 WPR and 1 BPR features combined, over 95% cross-validation classification accuracy was achieved using 3 different linear classifiers separately. These features may have potential as quantitative markers that discriminate精神分裂症患者和健康对照；但是，这需要对较大样本进行进一步验证。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |