| 1 | 欧元。J. Neurosci。2004年12月20日：3027-34 |
|---|---|
| PMID | 15579157 |
| 标题 | 腹侧海马病变对新生儿和成年大鼠的热和机械伤害感受的影响。 |
| 抽象的 | 这proper maturation of the hippocampus is essential for the development of different behaviours, including memory, pain responses and avoidance. The mechanisms involved in the neurodevelopment of nociception have also been implicated in several neuropsychiatric disorders. The neonatal lesion of the ventral hippocampus (VH) in rats, an animal model of精神分裂症，可以利用来研究动物行为的发育神经生物学。我们在开发的不同阶段检查了该动物模型中的伤害感受反应。大鼠幼崽在产后第7天通过双侧注射粘酸，然后在35、65和180天的年龄在35、65和180天的年龄中测试了热和机械伤害感受。使用的伤害性测试是热板（HP），PAW压力（PP）和尾部轻弹（TF）测试。另一组成年大鼠在VH中患有相同的病变，然后在28、56和168天进行相同的测试。与假对照相比，新生儿VH病变的大鼠仅在青春期后才显示出HP和PP测试的潜伏期降低。这TF测试显示65岁和180天的两组的潜伏期显着增加。患有VH病变的成年大鼠在所有测试期间没有发生重大变化。这些结果表明，VH的早期病变可以改变热和机械伤害感受涉及的神经机制的发展。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 2 | Biochim. Biophys. Acta 2004 Nov 1690: 238-49 |
| PMID | 15511631 |
| 标题 | A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. |
| 抽象的 | 人们对影响基因表达的多态性的可能性越来越兴趣，原因是包括人类疾病在内的大量可遗传人类表型变异。我们试图确定大脑表达基因启动子中的多态性是否通常具有功能。我们筛选了多态性的56个基因，以前据报道在精神分裂症s [Y. Hakak, J.R. Walker, C. Li, W.H. Wong, K.L. Davis, J.D. Buxbaum, V. Haroutunian, A.A. Fienberg, Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic精神分裂症。Proc。纳特。学院科学。98（2001）4746-4751。]。我们发现60种分布在31个基因上的变体。在两个细胞系中的报告基因测定中分析了代表28个不同推定启动子的77个单倍型。在单倍型中代表的总共54个序列变体中，根据高度保守的定义，有12个（或大约22％）起作用。这些是在八个基因的启动子中发现的：NPY，PCSK1，NEFL，KIAA0513，LMO4，HSPA1B，TF和MDH1。因此，我们估计，大脑表达基因中约有20-25％的启动子多态性是功能的，这可能是一种低估的。因此，我们的数据首次提供了经验证据，即至少在大脑表达的基因中，应为分子遗传研究提供高度优先级。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 3 | Biochim. Biophys. Acta 2004 Nov 1690: 238-49 |
| PMID | 15511631 |
| 标题 | A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. |
| 抽象的 | 人们对影响基因表达的多态性的可能性越来越兴趣，原因是包括人类疾病在内的大量可遗传人类表型变异。我们试图确定大脑表达基因启动子中的多态性是否通常具有功能。我们筛选了多态性的56个基因，以前据报道在精神分裂症s [Y. Hakak, J.R. Walker, C. Li, W.H. Wong, K.L. Davis, J.D. Buxbaum, V. Haroutunian, A.A. Fienberg, Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic精神分裂症。Proc。纳特。学院科学。98（2001）4746-4751。]。我们发现60种分布在31个基因上的变体。在两个细胞系中的报告基因测定中分析了代表28个不同推定启动子的77个单倍型。在单倍型中代表的总共54个序列变体中，根据高度保守的定义，有12个（或大约22％）起作用。这些是在八个基因的启动子中发现的：NPY，PCSK1，NEFL，KIAA0513，LMO4，HSPA1B，TF和MDH1。因此，我们估计，大脑表达基因中约有20-25％的启动子多态性是功能的，这可能是一种低估的。因此，我们的数据首次提供了经验证据，即至少在大脑表达的基因中，应为分子遗传研究提供高度优先级。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 4 | Mol. Psychiatry 2005 Mar 10: 309-22 |
| PMID | 15303102 |
| 标题 | Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. |
| 抽象的 | Major depressive disorder is one of the most common and devastating psychiatric disorders. To identify candidate mechanisms for major depressive disorder, we compared gene expression in the temporal cortex from 12 patients with major depressive disorder and 14 matched controls using Affymetrix HgU95A microarrays. Significant expression changes were revealed in families of genes involved in neurodevelopment, signal transduction and cell communication. Among these, the expression of 17 genes related to oligodendrocyte function was significantly (P < 0.05, fold change > 1.4) decreased in patients with major depressive disorder. Eight of these 17 genes encode structural components of myelin (CNP, MAG, MAL, MOG, MOBP, PMP22, PLLP, PLP1). Five other genes encode enzymes involved in the synthesis of myelin constituents (ASPA, UGT8), or are essential in regulation of myelin formation (ENPP2, EDG2,TF, KLK6). One gene, that is, SOX10, encodes a transcription factor regulating other myelination-related genes. OLIG2 is a transcription factor present exclusively in oligodendrocytes and oligodendrocyte precursors. Another gene, ERBB3, is involved in oligodendrocyte differentiation. In addition to myelination-related genes, there were significant changes in multiple genes involved in axonal growth/synaptic function. These findings suggest that major depressive disorder may be associated with changes in cell communication and signal transduction mechanisms that contribute to abnormalities in oligodendroglia and synaptic function. Taken together with other studies, these findings indicate that major depressive disorder may share common oligodendroglial abnormalities with精神分裂症and bipolar disorder. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 5 | Proc。纳特。学院科学。U.S.A. 2006 May 103: 7482-7 |
| PMID | 16641098 |
| 标题 | 人类QKI，人类少突胶质细胞相关基因的mRNA表达的潜在调节剂，参与精神分裂症。 |
| 抽象的 | 这quaking viable mouse mutation (qk(v)) is a deletion including the 5' regulatory region of the quaking gene (Qki), which causes body tremor and severe dysmyelination in mouse. The function of the human quaking gene, called quaking homolog KH domain RNA-binding (mouse) (QKI), is not well known. We have previously shown that QKI is a new candidate gene for精神分裂症。Here we show that human QKI mRNA levels can account for a high proportion (47%) of normal interindividual mRNA expression variation (and covariation) of six oligodendrocyte-related genes (PLP1, MAG, MBP,TF，Sox10和CDKN1B）在没有精神病诊断的个体的55个人脑尸检样本中。此外，紧密表达的髓磷脂相关基因（PLP1，MAG和TF) have decreased mRNA levels in 55精神分裂症与55个对照组相比，患者的大多数差异（68-96％）可以通过QKI-7KB的相对mRNA水平的差异来解释，同一QKI剪接变体先前证明在患者中被证明是下调的精神分裂症。综上所述，我们的结果表明，QKI水平可能以与小鼠相似的方式调节人脑中的少突胶质细胞分化和成熟。此外，我们假设先前观察到髓磷脂相关基因的活性降低精神分裂症可能是由于QKI剪接干扰引起的。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 6 | Proc。纳特。学院科学。U.S.A. 2006 May 103: 7482-7 |
| PMID | 16641098 |
| 标题 | 人类QKI，人类少突胶质细胞相关基因的mRNA表达的潜在调节剂，参与精神分裂症。 |
| 抽象的 | 这quaking viable mouse mutation (qk(v)) is a deletion including the 5' regulatory region of the quaking gene (Qki), which causes body tremor and severe dysmyelination in mouse. The function of the human quaking gene, called quaking homolog KH domain RNA-binding (mouse) (QKI), is not well known. We have previously shown that QKI is a new candidate gene for精神分裂症。Here we show that human QKI mRNA levels can account for a high proportion (47%) of normal interindividual mRNA expression variation (and covariation) of six oligodendrocyte-related genes (PLP1, MAG, MBP,TF，Sox10和CDKN1B）在没有精神病诊断的个体的55个人脑尸检样本中。此外，紧密表达的髓磷脂相关基因（PLP1，MAG和TF) have decreased mRNA levels in 55精神分裂症与55个对照组相比，患者的大多数差异（68-96％）可以通过QKI-7KB的相对mRNA水平的差异来解释，同一QKI剪接变体先前证明在患者中被证明是下调的精神分裂症。综上所述，我们的结果表明，QKI水平可能以与小鼠相似的方式调节人脑中的少突胶质细胞分化和成熟。此外，我们假设先前观察到髓磷脂相关基因的活性降低精神分裂症可能是由于QKI剪接干扰引起的。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 7 | int。J. Neuropsychopharmacol。2007年8月10日：547-55 |
| PMID | 17291372 |
| 标题 | 精神分裂症，情绪障碍和药物滥用的寡头异常。合并症，共享特征或分子表副词？ |
| 抽象的 | 这evidence implicating oligodendroglia in major mental disorders has grown significantly in the past few years. Microarray analysis revealed altered expression of oligodendroglia-related genes in multiple brain regions from several, clinically diverse groups of subjects with精神分裂症(SZ) as well as subjects with bipolar disorder (BD) and major depressive disorders (MDD), alcoholics and cocaine users. In line with gene expression findings, evidence for ultrastructural changes in white matter and altered oligodendroglia in these disorders were reported in neuroimaging and neuropathological studies. Changes in oligodendroglia-related genes reported in SZ, BD and MDD appear to display considerable similarities (particularly decreased expression of MAG, ERBB,TF, PLP1, MOG, MOBP, MOG), while changes in cocaine abuse and alcoholism are more diverse. Common oligodendroglial abnormalities might indicate aetiological or pathophysiological overlaps between different disorders. The possible mechanisms of oligodendroglial abnormalities may involve functional variations in oligodendroglia-related genes, epigenetic regulation of chromatin, DA system hyperactivity and other mechanisms. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 8 | Schizophr. Res. 2007 Feb 90: 15-27 |
| PMID | 17223013 |
| 标题 | 精神分裂症前扣带回皮质中髓鞘相关基因的转录本的表达。 |
| 抽象的 | 最近的一些研究发现，基因表达的变化与髓鞘和少突胶质细胞稳态有关精神分裂症。这些研究利用了微阵列和定量PCR（QPCR），即不允许直接对mRNA表达的直接检查的方法。此外，这些研究通常仅检查灰质匀浆中的转录本表达。在本研究中，我们检查了先前与髓鞘相关基因的表达精神分裂症by microarray or QPCR. Using in situ hybridization, we measured transcript expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), myelin-associated glycoprotein (MAG), transferrin (TF), quaking (QKI), gelsolin, myelin oligodendrocyte glycoprotein, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3, erbb2 interacting protein, motility-related protein-1, SRY-box containing gene 10, oligodendrocyte transcription factor 2, peripheral myelin蛋白22和claudin-11在受试者的前扣带回皮质（ACC）的灰色和白质中精神分裂症(n=41) and a comparison group (n=34). We found decreased expression of MAG, QKI,TF, and CNP transcripts in white matter. We did not find any differences in expression of these transcripts between medicated (n=31) and unmedicated (n=10)精神分裂症s, suggesting that these changes are not secondary to treatment with antipsychotics. Finally, we found significant positive correlations between QKI and MAG or CNP mRNA expression, suggesting that the transcription factor QKI regulates MAG and CNP expression. Our results support the hypothesis that myelination and oligodendrocyte function are impaired in精神分裂症。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 9 | Schizophr. Res. 2007 Feb 90: 15-27 |
| PMID | 17223013 |
| 标题 | 精神分裂症前扣带回皮质中髓鞘相关基因的转录本的表达。 |
| 抽象的 | 最近的一些研究发现，基因表达的变化与髓鞘和少突胶质细胞稳态有关精神分裂症。这些研究利用了微阵列和定量PCR（QPCR），即不允许直接对mRNA表达的直接检查的方法。此外，这些研究通常仅检查灰质匀浆中的转录本表达。在本研究中，我们检查了先前与髓鞘相关基因的表达精神分裂症by microarray or QPCR. Using in situ hybridization, we measured transcript expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), myelin-associated glycoprotein (MAG), transferrin (TF), quaking (QKI), gelsolin, myelin oligodendrocyte glycoprotein, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3, erbb2 interacting protein, motility-related protein-1, SRY-box containing gene 10, oligodendrocyte transcription factor 2, peripheral myelin蛋白22和claudin-11在受试者的前扣带回皮质（ACC）的灰色和白质中精神分裂症(n=41) and a comparison group (n=34). We found decreased expression of MAG, QKI,TF, and CNP transcripts in white matter. We did not find any differences in expression of these transcripts between medicated (n=31) and unmedicated (n=10)精神分裂症s, suggesting that these changes are not secondary to treatment with antipsychotics. Finally, we found significant positive correlations between QKI and MAG or CNP mRNA expression, suggesting that the transcription factor QKI regulates MAG and CNP expression. Our results support the hypothesis that myelination and oligodendrocyte function are impaired in精神分裂症。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 10 | J Psychiatr Res 2008 9月42日：877-83 |
| PMID | 18045615 |
| 标题 | 转铁蛋白基因的多态性与中国汉族中的精神分裂症有关。 |
| 抽象的 | 最近的一些研究提供了证据，表明少突胶质细胞和髓磷脂功能的异常可能有助于病理学精神分裂症。Transferrin (TF), an iron transport glycoprotein playing an important role in synthesis of myelin and the development of oligodendrocytes, has been identified as down-regulated expression in精神分裂症brain by microarray, quantitative PCR and in situ hybridization method. In order to further assess the role ofTF在精神分裂症，我们检查了七个多态性TF使用由326个组成的中国汉族受试者的集合样本精神分裂症患者和344个健康对照。在这项研究中分析了四个单核苷酸多态性（SNP），即RS4481157，RS3811655，RS6762415和RS1405022。我们的结果表明，一个内含子SNP与精神分裂症(rs3811655: allele C>G, P=1.34E-6, OR=1.89, 95% CI=1.46-2.46; genotype P=3.72E-6). Two haplotypes A-C and G-G constructed of rs4481157-rs3811655 also revealed significant associations with精神分裂症（全局p = 0.0001）。我们的发现支持TF基因可能参与精神分裂症在the Chinese Han population. However, further studies are needed to confirm these findings in other populations and to identify functional variants inTF这可能与发病机理有关。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 11 | Schizophr. Res. 2009 Jul 112: 54-64 |
| PMID | 19447584 |
| 标题 | Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder. |
| 抽象的 | Deficits in the expression of oligodendrocyte and myelin genes have been described in numerous cortical regions in精神分裂症和情感障碍；但是，对皮层结构的关注很少。在这里，我们采用定量实时PCR检查了17个基因的mRNA表达，这些基因由少突胶质细胞前体（OLP）及其衍生物（包括星形胶质细胞）表达。检查了四个皮层下区域（前腹（AV）和中腹丘脑核（MDN），内部胶囊（IC）（IC）和壳核（PUT））在受试者的验尸材料中（死亡时25-68岁），没有已知的精神病病史（NCS）以及主题精神分裂症(SZ), major depressive disorder (MDD), and bipolar disorder (BPD). In all regions examined, genes expressed after the terminal differentiation of oligodendrocytes tended to have lower levels of mRNA expression in subjects with SZ compared to NCs. These differences were statistically significant across regions for four genes (CNP, GALC, MAG and MOG) and approached significance forTF。在MDD中没有任何基因表达。仅有的TF在BPD中被表达，仅在IC中。相比之下，相对于NCS，所有精神病学组的两个星形胶质细胞相关基因（GFAP和ALDH1L1）的平均表达水平较高。这些差异相对于NCS而言，SZ和MDD达到了统计学意义。没有诊断相互作用的年龄。大多数年龄回归对少突胶质细胞相关基因的表达产生负斜率。GFAP但不是ALDH1L1表达与MDN，AV和PUT中的年龄显着且正相关。在主体组中，两个星形胶质细胞基因的表达与除PUT之外的所有区域中的累积神经摄影暴露高度相关。在累积的神经诱变和与成熟的少突胶质细胞以及与双能OLP相关的基因表达之间以及与双能OLP相关的基因的表达之间，在某些区域也观察到了显着的正相关。观察到星形胶质细胞基因的mRNA表达和由终末分化的少突胶质细胞表达的基因之间观察到了多个阴性相关性。这些数据是在髓磷脂周转和精神病的潜在影响以及药物对OLPS发育命运的背景下进行了讨论。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 12 | Neuropsychiatr dis Treat 2009 -1 5：15-22 |
| PMID | 19557095 |
| 标题 | Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders. |
| 抽象的 | 我们的目的是调查新生儿双边在腹侧海马中的给药是否会导致与精神分裂症。在Wistar雄性幼犬中用Lidocaine制成新生儿腹腹膜病变（NVH病变）。形成了两组，第一次接收的利多卡因（4杯/0.3 mul），第二次是同等体积的车辆。在第35天和第56天，两组都经过了社交接触，固定性固定而固定和背侧固定性，开放式野外运动和尾部（尾部轻弹）（TF) latency after a painful heat stimulus. All animals were then killed. Coronal cuts (7 mum) of the brain were obtained and each brain section was stained with cresyl violet-eosin. The animals which received the nVH lesion with lidocaine had decreased social interaction at both ages. The rats with lesions, only at day 58 postnatal, increased their distance traveled and ambulatory time, with a decrease in their nonambulatory and reset time. The rats with lesions had a longer duration of immobility caused by clamping the neck and a longer dorsal immobility at both days 34 and 57 compared to control rats. The lidocaine-treated group spent less time to deflect the tail compared to the control group at postpubertal age. The neonatal bilateral administration of lidocaine into the ventral hippocampus caused some alterations, such as chromatin condensation, nucleolus loss, and cell shrinkage, but glial proliferation was not seen. Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 13 | BMC Syst Biol 2010 -1 4：10 |
| PMID | 20156358 |
| 标题 | 一种新型的microRNA和转录因子介导的精神分裂症调节网络。 |
| 抽象的 | 精神分裂症是一种复杂的脑部疾病，具有尚未阐明的分子机制。先前的研究表明，基因表达的变化可能在病因中起重要作用精神分裂症, and that microRNAs (miRNAs) and transcription factors (TFS）是该基因表达的主要调节剂。到目前为止，几个mirna-TF介导的调节模块已验证。我们假设mirnas和TFS可能扮演组合调节角色精神分裂症genes and, thus, explored miRNA-TFregulatory networks in精神分裂症。 We identified 32 feed-forward loops (FFLs) among our compiled精神分裂症-related miRNAs,TFS和基因。我们的评估表明，这些观察到的FFL显着丰富了精神分裂症genes. By converging the FFLs and mutual feedback loops, we constructed a novel miRNA-TFregulatory network for精神分裂症。我们的分析表明，EGR3和HSA-MIR-195是该调节网络中的核心调节剂。接下来，我们提出了一个模型，该模型强调了神经系统中涉及信号通路和调节网络的EGR3和miRNA。最后，我们建议位于miRNA，其目标部位和TFBSs, which may have an effect in精神分裂症gene regulation. This study provides many insights on the regulatory mechanisms of genes involved in精神分裂症。It represents the first investigation of a miRNA-TF复杂疾病的调节网络，如精神分裂症。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 14 | 大脑行为。免疫。2011年8月25日：1162-9 |
| PMID | 21421043 |
| 标题 | TREM-1和DAP12表达在单核细胞疼痛。病人就医时最多的主诉ts with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors. |
| 抽象的 | 免疫激活是精神分裂症(SCZ), bipolar disorder (BD) and unipolar major depressive disorder (MDD). The triggering receptor expressed on myeloid cells 1 (TREM-1), its' adaptor molecule DAP12 and their transcription factor (TF)在炎症和PU.1是重要的关键基因expressed in activated monocytes and microglia. To test: (1) if the expressions of TREM-1, DAP12 and PU.1 are increased in monocytes of patients with severe psychiatric disorders and (2) if PU.1 and theTFs ATF3和EGR3（在先前的研究中发现了显着增加的单核细胞基因）参与了TREM-1和DAP12表达的调节。 使用Q-PCR，我们研究了TREM-1，DAP12，PU.1，A的基因表达TF73例严重精神病患者的单核细胞中的3和EGR3（最近27例SCZ患者，22名BD患者和24名MDD患者）和79个健康对照（HC）。在硅中使用TFbinding site prediction and in vivo chromatin immunoprecipitation (ChIP), we studied the actual binding of EGR3, ATF3和PU.1向TREM-1和DAP12的启动子区域。 1. SCZ和BD患者的单核细胞中TREM-1基因表达增加，并且在MDD患者的单核细胞中倾向于增加。2. SCZ，BD和MDD患者的单核细胞中的DAP12基因水平既没有升高。3. MDD患者的单核细胞中的PU.1表达水平升高，但SCZ和BD患者的表达水平却没有升高。4. TREM-1表达水平特别与A相关TF3和EGR3表达水平，DAP12表达水平特别与PU.1表达水平相关。5.我们发现使用绑定位点预测和芯片测定法TFS EGR3和ATF3确实与TREM-1启动子绑定了PU.1与TREM-1和DAP12启动子结合。 In this study, we provide evidence that TREM-1 gene expression is significantly increased in monocytes of SCZ and BD patients and that the TREM-1 gene is a target gene of theTFs ATF3 and EGR3. In MDD patients, PU.1 gene expression was increased with a tendency for TREM-1 gene over expression. Our observations support the concept that monocytes are in a pro-inflammatory state in severe psychiatric conditions and suggest differences in monocyte inflammatory set points between SCZ, BD and MDD. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 15 | Arch Pediatr Adolesc Med 2011年1月165日：16-21 |
| PMID | 21199975 |
| 标题 | 暴露于亲密伴侣暴力的儿童创伤后应激障碍的社区治疗：一项随机对照试验。 |
| 抽象的 | To evaluate community-provided trauma-focused cognitive behavior therapy (TF-CBT) compared with usual community treatment for children with intimate partner violence (IPV)-related posttraumatic stress disorder (PTSD) symptoms. Randomized controlled trial conducted using blinded evaluators. 在2004年9月1日至2009年6月30日之间，在社区IPV中心进行招聘，筛查和治疗。 Of 140 consecutively referred 7- to 14-year-old children, 124 participated. 儿童和母亲被随机分配接受8个会议TF-CBT or usual care (child-centered therapy). Total child PTSD symptoms assessed using child and parent structured interview (Kiddie Schedule for Affective Disorders and精神分裂症, Present and Lifetime Version [K-SADS-PL]) and self-report (University of California at Los Angeles PTSD Reaction Index [RI]). Secondary child outcomes were scores on the K-SADS-PL (PTSD symptom clusters), Screen for Child Anxiety Related Emotional Disorders (SCARED) (anxiety), Children's Depression Inventory (depression), Kaufman Brief Intelligence Test (cognitive functioning), and Child Behavior Checklist (total behavior problems). 使用最后一次观察的意图对治疗分析显示出卓越的结果TF-CBT on the total K-SADS-PL (mean difference, 1.63; 95% confidence interval [CI], 0.44-2.82), RI (mean difference, 5.5; 95% CI, 1.37-9.63), K-SADS-PL hyperarousal (mean difference, 0.71; 95% CI, 0.22-1.20), K-SADS-PL avoidance (0.55; 0.07-1.03), and SCARED (mean difference, 5.13; 95% CI, 1.31-8.96). Multiple imputation analyses confirmed most of these findings. TheTF-CBT完成者的PTSD诊断缓解明显更大（？（2）= 4.67，p = .03），严重不良事件的严重不良事件大大减少。 社区TF-CBT有效地改善了儿童IPV相关的PTSD和焦虑。 clinicaltrials.gov Identifier: NCT00183326. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 16 | Mol. Biol. Rep. 2012 Mar 39: 2253-8 |
| PMID | 21643746 |
| 标题 | 克罗地亚精神分裂症和精神分裂症患者中的HFE突变和转铁蛋白C1/C2多态性。 |
| 抽象的 | 这aim of this study was to investigate the possible influence of hemochromatosis gene mutations (HFE-C282Y and H63D) and transferrin gene C2 variant (TF-c2）易感性精神分裂症and schizoaffective disorder and/or age at first hospital admission. Genotyping was performed in 176 Croatian patients and 171 non-psychiatric Croatian controls using PCR-RFLP analyses. Regarding the H63D mutation, allele and genotype frequencies reached boundary statistical significance. Other allele and genotype distributions were not significantly different between two groups. We also analyzed age at first hospital admission as a continuous variable using the non-parametric Mann-Whitney U-test and Kruskal-Wallis test, and multiple regression analysis. The results of these tests were negative. We concluded that investigated HFE mutations andTF-C2 variant are not high-risk genetic variants for精神分裂症/schizoaffective disorder in our population. Also our data do not support their impact on age at onset of the first psychotic symptoms. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 17 | prog。神经心理药物。生物。精神病学2013年10月46日：92-7 |
| PMID | 23838275 |
| 标题 | Contrast, motion, perceptual integration, and neurocognition in schizophrenia: the role of fragile-X related mechanisms. |
| 抽象的 | Recent studies demonstrated a reduced expression of Fragile X Mental Retardation Protein (FMRP), an RNA binding protein and translation regulator, in the brain and peripheral lymphocytes of patients with精神分裂症。低FMRP水平可能与神经发育过程受损和突触可塑性有关。在这里，我们研究了周围FMRP级别，视觉感知（对比灵敏度，感知整合，运动/形式感知）与神经心理学功能之间的关系精神分裂症as measured with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results revealed that patients with精神分裂症与对照个体相比，外周淋巴细胞中的FMRP水平较低。我们发现，在低空间和高时间频率，感知整合和运动感知下，FMRP水平与对比度灵敏度之间的显着相关性。FMRP水平与神经心理学功能之间的关系不及视觉感知情况下的关系，对RBAN的注意力最大。FMRP水平与高空间和低时间频率和形式感知下的对比度敏感性无关。这种数据模式让人联想到在脆弱X综合征（FXS）患者中观察到的模式。这些结果表明，FMRP可能与精神分裂症，可能通过调节神经发育，可塑性，GABA - 凝胶和谷氨酸能神经传递。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 18 | 行为。脑部。2013年3月240日：134-45 |
| PMID | 23195116 |
| 标题 | 通过选择性繁殖大鼠的行为分析来表征基因环境相互作用：NMDA受体抑制和社会隔离的影响。 |
| 抽象的 | Gene-environment interactions have an important role in the development of psychiatric disorders. To generate and validate a new substrain of rats with signs related to精神分裂症, we used selective breeding after postweaning social isolation and chronic ketamine treatment through several generations of animals and compared the subsequent strain to naive rats that were not genetically manipulated. We further investigated whether social isolation and ketamine treatment augmented the appearance of精神分裂症- 这些大鼠的标志。研究了四个实验组（n = 6-15只大鼠/组）：无治疗方法的天真大鼠（nano）；幼稚的大鼠与断奶后的社会隔离和氯胺酮治疗（NATR）；第15代没有任何治疗的有选择性繁殖动物（SELNO）或有选择性的繁殖大鼠，均具有分离和氯胺酮治疗（SELTR）。惊吓反应，尾灯和新颖的物体识别测试用于将动物分类为低风险或高风险精神分裂症。Reduced pain sensitivity, higher degree of the startle reaction, disturbed prepulse inhibition, altered motor activity and decreased differentiation index in the memory test were observed in the 15th generation of the substrain, along with enhanced grooming behavior. Five functional indices (TF等待时间，惊吓反应，预硫次抑制，分化指数和修饰活性从0到2，对汇总分数的分析表明，纳米组的总体指示是最低的。精神分裂症- 类似的迹象，而SELTR动物的得分最高，这表明可遗传和环境因素在行为改变的产生中都很重要。我们假设在这种复杂处理后进一步繁殖可能会导致有效可靠的动物模型精神分裂症。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 19 | 行为。脑部。2013年3月240日：134-45 |
| PMID | 23195116 |
| 标题 | 通过选择性繁殖大鼠的行为分析来表征基因环境相互作用：NMDA受体抑制和社会隔离的影响。 |
| 抽象的 | Gene-environment interactions have an important role in the development of psychiatric disorders. To generate and validate a new substrain of rats with signs related to精神分裂症, we used selective breeding after postweaning social isolation and chronic ketamine treatment through several generations of animals and compared the subsequent strain to naive rats that were not genetically manipulated. We further investigated whether social isolation and ketamine treatment augmented the appearance of精神分裂症- 这些大鼠的标志。研究了四个实验组（n = 6-15只大鼠/组）：无治疗方法的天真大鼠（nano）；幼稚的大鼠与断奶后的社会隔离和氯胺酮治疗（NATR）；第15代没有任何治疗的有选择性繁殖动物（SELNO）或有选择性的繁殖大鼠，均具有分离和氯胺酮治疗（SELTR）。惊吓反应，尾灯和新颖的物体识别测试用于将动物分类为低风险或高风险精神分裂症。Reduced pain sensitivity, higher degree of the startle reaction, disturbed prepulse inhibition, altered motor activity and decreased differentiation index in the memory test were observed in the 15th generation of the substrain, along with enhanced grooming behavior. Five functional indices (TF等待时间，惊吓反应，预硫次抑制，分化指数和修饰活性从0到2，对汇总分数的分析表明，纳米组的总体指示是最低的。精神分裂症- 类似的迹象，而SELTR动物的得分最高，这表明可遗传和环境因素在行为改变的产生中都很重要。我们假设在这种复杂处理后进一步繁殖可能会导致有效可靠的动物模型精神分裂症。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 20 | Genes Brain Behav. 2013 Mar 12: 147-65 |
| PMID | 23173912 |
| 标题 | A hierarchical coherent-gene-group model for brain development. |
| 抽象的 | 我们已经描述了一种使用由转录因子控制的相干基因组的概念来分析脑基因表达上可用数据的策略（TFS）。在大脑发育过程中建立了基因表达模式的层次模型，该模型确定了假定的基因在功能上编码。对相关信号通路和过程的分析显示，与神经发生/突触发生有关的时间基因表达模式不同。我们确定了分层的树TFnetworks that determined the patterns of genes expressed during brain development. Some 'masterTF在层次结构的最高级别的s'调节基因组的表达。少数大师的活动增强/减少TFs may explain paradoxes raised by the genetic determination of autism-spectrum disorders and精神分裂症。我们的分析显示基因TF与这些疾病相关的网络，与这些疾病相关，这些疾病表现出两个表达最大的表达最大，一个在产后发育的早期发育时期，与这些疾病源于产后时期的观点一致，并且是在产后时期发展的。达到最终的神经和行为表型，具有调节每个时期的不同基因集。我们提出了一种基于相关表达的时间模式的药物设计策略TFs. Ligands targeting specificTFs can be designed to specifically affect the pathological evolution of the mutated gene(s) in genetically predisposed patients when administered at relevant stages of brain development. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 21 | Neuron 2014 Aug 83: 894-905 |
| PMID | 25088363 |
| 标题 | Sensory integration in mouse insular cortex reflects GABA circuit maturation. |
| 抽象的 | Insular cortex (IC) contributes to a variety of complex�brain functions, such as communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive content. How the IC acquires its integrative properties remains unexplored. We compared the emergence of multisensory integration (MSI) in the IC of behaviorally distinct mouse strains. While adult C57BL/6 mice exhibited robust MSI, this capacity was impaired in the inbred BTBR T+TF/J mouse model of idiopathic autism. The�deficit reflected weakened ?-aminobutyric acid (GABA) circuits and compromised postnatal pruning of cross-modal input. Transient pharmacological enhancement by diazepam in BTBR mice during an early sensitive period rescued inhibition and integration in the adult IC. Moreover, impaired MSI was common across three other monogenic models (GAD65, Shank3, and Mecp2 knockout mice) displaying behavioral phenotypes and parvalbumin-circuit�abnormalities. Our findings offer developmental insight into a key neural circuit relevant to neuropsychiatric conditions like精神分裂症和自闭症。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 22 | INT J Psychophyoliol 2014 2月91日：104-20 |
| PMID | 24333745 |
| 标题 | Auditory event-related potentials and ? oscillations in the psychosis prodrome: neuronal generator patterns during a novelty oddball task. |
| 抽象的 | 先前的研究表beplay苹果手机能用吗明，在主动和被动听觉范式中获得的与事件相关电位（ERP），这些范式表现出异常的神经认知功能精神分裂症，可以提供有用的工具来预测过渡到精神病。除了ERP措施外，脑电图α的调制减少，反映了抑制无关信息所需的自上而下的控制，还揭示了注意力缺陷精神分裂症及其前驱阶段。采用三刺新颖的奇怪任务，从22名临床高风险（CHR）患者和20个健康对照组中记录了鼻子引用的48通道ERP，检测到目标音调（12％概率，500Hz；按钮按下）（76％）（76％），350Hz）和新颖的声音（12％）。在电流源密度（CSD）转换EEG时期（-200至1000ms）之后，在刺激后，为每个位点获得了与事件相关的光谱扰动，并通过无限制的时间（无限制的时间）简化（TF) principal components analysis (PCA). Alpha event-related desynchronization (ERD) as measured byTF610 - 9因素(在610 ms谱峰值延迟和9Hz; 31.9% variance) was prominent over right posterior regions for targets, and markedly reduced in CHR patients compared to controls, particularly in three patients who later developed psychosis. In contrast, low-frequency event-related synchronization (ERS) distinctly linked to novels (260-1; 16.0%; mid-frontal) and N1 sink across conditions (130-1; 3.4%; centro-temporoparietal) did not differ between groups. Analogous time-domain CSD-ERP measures (temporal PCA), consisting of N1 sink, novelty mismatch negativity (MMN), novelty vertex source, novelty P3, P3b, and frontal response negativity, were robust and closely comparable between groups. Novelty MMN at FCz was, however, absent in the three converters. In agreement with prior findings, alpha ERD and MMN may hold particular promise for predicting transition to psychosis among CHR patients. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 23 | Mol. Psychiatry 2014 Mar 19: 294-301 |
| PMID | 23439483 |
| 标题 | Neurodevelopmental and neuropsychiatric disorders represent an interconnected molecular system. |
| 抽象的 | Many putative genetic factors that confer risk to neurodevelopmental disorders such as autism spectrum disorders (ASDs) and X-linked intellectual disability (XLID), and to neuropsychiatric disorders including attention deficit hyperactivity disorder (ADHD) and精神分裂症(深圳)已确定个人跳水rse human populations. Although there is significant aetiological heterogeneity within and between these conditions, recent data show that genetic factors contribute to their comorbidity. Many studies have identified candidate gene associations for these mental health disorders, albeit this is often done in a piecemeal fashion with little regard to the inherent molecular complexity. Here, we sought to abstract relationships from our knowledge of systems level biology to help understand the unique and common genetic drivers of these conditions. We undertook a global and systematic approach to build and integrate available data in gene networks associated with ASDs, XLID, ADHD and SZ. Complex network concepts and computational methods were used to investigate whether candidate genes associated with these conditions were related through mechanisms of gene regulation, functional protein-protein interactions, transcription factor (TF）和microRNA（miRNA）结合位点。尽管我们的分析表明，与四种疾病相关的遗传变异可能发生在相同的分子途径和功能结构域，包括突触传播，但存在一些变异模式可以定义疾病之间的显着差异。特别令人感兴趣的是位于基因间区域中的DNA变异TFS或miRNA。我们的方法提供了一个假设的框架，该框架将有助于发现和分析与神经发育和神经精神疾病相关的候选基因。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 24 | Schizophr Bull 2015 Nov -1: -1 |
| PMID | 26609121 |
| 标题 | 探索精神分裂症中的转录因子 - 微红菌共同调节网络。 |
| 抽象的 | 转录因素（TFs) and microRNAs (miRNAs) have been recognized as 2 classes of principal gene regulators that may be responsible for genome coexpression changes observed in精神分裂症(SZ). 这项研究的目的是（1）在3个mRNA表达微阵列数据集中确定差异表达的基因（DCG）；（2）探索DCG之间的潜在相互作用，并在我们的数据集中鉴定出的miRNA差异表达，该数据集由早发性SZ患者和健康对照组成；（3）验证某些关键转录本的表达水平；（4）使用策划数据库探索DCG的可药物。 We detected a differential coexpression network associated with SZ and found that 9 out of the 12 regulators were replicated in either of the 2 other datasets. Leveraging the differentially expressed miRNAs identified in our previous dataset, we constructed a miRNA-TF- 与SZ相关的网络，包括EGR1-MIR-124-3P-SKIL馈送回路。我们的实时定量PCR分析表明，与对照组相比，miR-124-3p的过表达，SZ患者血液中冰和EGR1的表达不足，而miR-124-3p和冰mRNA水平的变化方向在12周的治疗周期后，SZ病例逆转。我们的可药物分析表明，其中许多基因具有药物靶标的潜力。 Together, our results suggest that coexpression network abnormalities driven by combinatorial and interactive action fromTFS和miRNA可能有助于SZ的发展，并与该疾病的临床治疗有关。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 25 | Cereb. Cortex 2015 May 25: 1133-42 |
| PMID | 24293564 |
| 标题 | Cognitive abilities on transitive inference using a novel touchscreen technology for mice. |
| 抽象的 | 认知能力在neurodevelopme受损ntal disorders, including autism spectrum disorder (ASD) and精神分裂症。Preclinical models with strong endophenotypes relevant to cognitive dysfunctions offer a valuable resource for therapeutic development. However, improved assays to test higher order cognition are needed. We employed touchscreen technology to design a complex transitive inference (TI) assay that requires cognitive flexibility and relational learning. C57BL/6J (B6) mice with good cognitive skills and BTBR T+TF/j（BTBR）是一种具有认知缺陷的ASD模型，在简单而复杂的触摸屏测定中评估。B6和BTBR都获得了视觉歧视和逆转。当将4个刺激对散布时，BTBR在Ti的组件上显示出缺陷，需要灵活的集成知识。BTBR在A> e推理上显示出损伤，类似于ASD中的A> E缺陷。B6和BTBR小鼠均在B> D比较上达到标准，与B> D损伤不同精神分裂症。这se results demonstrate that mice are capable of complex discriminations and higher order tasks using methods and equipment paralleling those used in humans. Our discovery that a mouse model of ASD displays a TI deficit similar to humans with ASD supports the use of the touchscreen technology for complex cognitive tasks in mouse models of neurodevelopmental disorders. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 26 | 澳大利亚精神病学2015年2月23日：54-8 |
| PMID | 25512971 |
| 标题 | 致命的折磨 - 从精神病驱动的索引犯罪犯罪：法医心理治疗，创伤疗法和矩阵中的案例研究。 |
| 抽象的 | 本文提出了法医住院医生的情况。 诊断为法医住院的案例研究精神分裂症that as part of his rehabilitation program received 19 sessions of therapy (i.e. grief counselling, Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) and imagery rescripting). The following measures were administered pre- and post-treatment: (a) The Depression Anxiety Stress Scale (DASS), to measure symptoms of depression, anxiety and stress; (b) The Impact of Events Scale-Revised (IES-R), to measure post-traumatic stress symptoms; and (c) The Trauma Attachment and Beliefs Scale (TABS), to measure disruption in beliefs about self and others. 完成治疗后，他显示出创伤后应激障碍（PTSD），抑郁，焦虑和压力症状的减少。 在相关的情况下，必须与精神病症状一起评估和治疗，在法医住所种群中的创伤和PTSD相关症状。TF-CBT在当前的案例研究中有效减少PTSD症状，应被视为对法医住院群体的干预。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 27 | int。J. Biochem。细胞生物。2016年1月70日：82-91 |
| PMID | 26592196 |
| 标题 | Chlorpromazine inhibits mitochondrial apoptotic pathway via increasing expression of tissue factor. |
| 抽象的 | 氯丙嗪（CPZ）是一种广泛使用的抗精神病药，对多巴胺受体有拮抗作用。积累的证据表明，CPZ在各种毒性和凋亡模型中起神经保护作用。但是，促成这种保护作用的基本机制尚不清楚。在这里，我们评估了CPZ对神经元系统中线粒体凋亡途径的影响。较高水平的B细胞淋巴瘤2（BCL-2）和组织因子（TF) but lower apoptotic rate were found in hippocampus of CPZ-treated精神分裂症患者与非静脉治疗的对照相比。此外，大鼠CPZ的短期和长期治疗都可以上调Bcl-2和TFwith no cytotoxic effects. In the in vitro experiment, expression of Bcl-2 was up-regulated in the C6 glioma cells transfected with pEGFP-N1-TF重组质粒。此外，在另一种独立的大鼠凋亡模型中，与仅用酒精管理的组相比，CPZ预测的大鼠的大脑显示出裂解的caspase-3，细胞色素C和BAX的表达较低，但Bcl-2和Bcl-2和Bax的表达较高TF。我们的数据表明，CPZ通过上调通过抑制线粒体凋亡途径的激活来发挥其神经元保护作用TFexpression, thus providing new insight into CPZ function and application. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 28 | Schizophr Bull 2016 May 42: 693-702 |
| PMID | 26609122 |
| 标题 | Trauma-Focused Treatment in PTSD Patients With Psychosis: Symptom Exacerbation, Adverse Events, and Revictimization. |
| 抽象的 | Most clinicians refrain from trauma treatment for patients with psychosis because they fear symptom exacerbation and relapse. This study examined the negative side effects of trauma-focused (TF) treatment in patients with psychosis and posttraumatic stress disorder (PTSD). Analyses were conducted on data from a single-blind randomized controlled trial comparingTFtreatment (N = 108; 8 sessions prolonged exposure or eye movement desensitization) and waiting list (WL; N = 47) among patients with a lifetime psychotic disorder and current chronic PTSD. Symptom exacerbation, adverse events, and revictimization were assessed posttreatment and at 6-month follow-up. Also investigated were symptom exacerbation after initiation ofTFtreatment and the relationship between symptom exacerbation and dropout. 任何症状加剧（PTSD，妄想症或抑郁症）往往在WL状况下更频繁地发生。第一个之后TF治疗课程，PTSD症状加剧并不常见。在前两个会议期间，幻觉，解离或自杀性没有增加。在此期间，偏执狂显着下降。辍学与症状加剧无关。与WL条件相比TFtreatment condition reported an adverse event (OR = 0.48, P = .032). Surprisingly, participants receivingTF治疗的重复可能性明显较小（OR = 0.40，p = .035）。 在这些参与者中TFtreatment did not result in symptom exacerbation or adverse events. Moreover,TFtreatment was associated with significantly less exacerbation, less adverse events, and reduced revictimization compared with the WL condition. This suggests that conventionalTF治疗方案可以安全地用于精神病患者，没有负面影响。 |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |
| 29 | Psychol Psychother 2016 Jun 89: 117-32 |
| PMID | 26202461 |
| 标题 | Process analysis of trauma-focused cognitive behavioural therapy for individuals with schizophrenia. |
| 抽象的 | 这rapeutic alliance, modality, and ability to engage with the process of therapy have been the main focus of research into what makes psychotherapy successful. Individuals with complex trauma histories or精神分裂症are suggested to be more difficult to engage and may be less likely to benefit from therapy. This study aimed to track the in-session 'process' of working alliance and emotional processing of trauma memories for individuals with精神分裂症。 该研究利用了一项开放的随机临床试验的治疗部门的会话记录，调查了以创伤为中心的认知行为疗法（TF-CBT) for individuals with精神分裂症（n =�26）。 Observer measures of working alliance, emotional processing, and affect arousal were rated at early and late phases of therapy. Correlation analysis was undertaken for process measures. Temporal analysis of expressed emotions was also reported. 在整个疗法中建立并维持工作联盟；但是，关于目标的协议在后期减少。参与者似乎能够进行情感处理，但不能达到成功认知重组的所需水平。 This study undertook novel exploration of process variables not usually explored in CBT. It is also the first study of process forTF-CBT with individuals with精神分裂症。This complex clinical sample showed no difficulty in engagement; however, they may not be able to fully undertake the cognitive-emotional demands of this type of therapy. Clinical and research implications and potential limitations of these methods are considered. This sample showed no difficulties engaging withTF-CBT and forming a working alliance. However, the participants may not have achieved a level of active involvement required for successful cognitive restructuring of trauma memories. This discrepancy may relate to the mediating role of both working alliance and cognitive-emotional processing. The results underscore the importance of therapists understanding the relationship between alliance and other process factors which may be implicit in facilitating change. |
| SCZ关键字 | 精神分裂症, schizophrenic, schizophrenics |