| Abstract |
Epidemiological studies have indicated that both maternal bacterial and viral infections during pregnancy increase the risk ofschizophreniaamong offspring, but to date there is not clear explanation for this increased risk. Previously, the decreased C4b-binding protein (C4BP), a potent circulating soluble inhibitor of the classical and lectin pathways of complement, was reported to be associated with risk ofschizophrenia. Here, we analyzed 4 common single nucleotide polymorphisms (SNPs) ofC4BPBand 5 SNPs of C4BPA in a group of 556schizophreniapatients and a matched group of 610 healthy controls to see if the genesC4BPBand C4BPA, which encode C4BP, may confer a susceptibility toschizophrenia. Comparing the genotype and allele frequencies of those SNPs between cases and controls, we found no association between theC4BPB/C4BPA variants andschizophrenia. Our results provided preliminary evidence thatC4BPB/ C4BPA不得授予感病体ibility toschizophreniaamong Han Chinese. Further genetic studies from large-scale population are required to obtain more conclusive results. |