| 1 | Eur. Psychiatry 2005 Jan 20: 45-9 |
|---|---|
| PMID | 15642443 |
| Title | An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia. |
| Abstract | Dysfunctions of glutamatergic and GABAergic neurotransmission are two important hypotheses for the pathogenesis of精神分裂症. Thus, genes in the pathway are candidates for精神分裂症susceptibility. Phosphate-activated glutaminase (GLS), glutamine synthetase (GLUL), glutamic acid decarboxylase (GAD), GABA transaminase (ABAT) and succinic semialdehyde dehydrogenase (ALDH5A1) are five primary enzymes in glutamate and GABA synthetic and degradative pathway. In order to investigate the possible involvement of these genes in the development of paranoid精神分裂症, we genotyped 80 paranoid精神分裂症s from northern China and 108 matched controls by polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) methods or directly sequencing of PCR product. Seven SNPs were found to be polymorphic in the population investigated. No significant differences in the genotype distributions or allele frequencies between patients and controls were found. Therefore, we conclude the polymorphisms studied in the five genes do not play major roles in pathogenesis of paranoid精神分裂症in the population investigated. |
| SCZ Keywords | 精神分裂症, schizophrenics |
| 2 | Eur. Psychiatry 2005 Jan 20: 45-9 |
| PMID | 15642443 |
| Title | An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia. |
| Abstract | Dysfunctions of glutamatergic and GABAergic neurotransmission are two important hypotheses for the pathogenesis of精神分裂症. Thus, genes in the pathway are candidates for精神分裂症susceptibility. Phosphate-activated glutaminase (GLS), glutamine synthetase (GLUL), glutamic acid decarboxylase (GAD), GABA transaminase (ABAT) and succinic semialdehyde dehydrogenase (ALDH5A1) are five primary enzymes in glutamate and GABA synthetic and degradative pathway. In order to investigate the possible involvement of these genes in the development of paranoid精神分裂症, we genotyped 80 paranoid精神分裂症s from northern China and 108 matched controls by polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) methods or directly sequencing of PCR product. Seven SNPs were found to be polymorphic in the population investigated. No significant differences in the genotype distributions or allele frequencies between patients and controls were found. Therefore, we conclude the polymorphisms studied in the five genes do not play major roles in pathogenesis of paranoid精神分裂症in the population investigated. |
| SCZ Keywords | 精神分裂症, schizophrenics |