| Abstract |
Previous literature shows that children who later developschizophreniahave elevated rates of prenatal and perinatal complications (PPCS) and neuropsychological deficits in childhood. However, little is known about the relationship of these risk factors to each other. We evaluated the relationship betweenPPCS和神经心理功能在一个7岁large epidemiological study of pregnancy, birth, and development: the National Collaborative Perinatal Project (NCPP). Thirteen standardized measures of cognitive abilities were acquired on 11,889 children at approximately age 7. Principal components analysis was used to create three neuropsychological measures: academic achievement skills, verbal-conceptual abilities, and perceptual-motor abilities. We measured the relationship between these factors and three measures ofPPCS: low birth weight (LBW), probable hypoxicischemic complications, and chronic hypoxia. All three measures ofPPCSwere significantly associated with lower neuropsychological performance, after controlling for various confounders. LBW had the strongest association with neuropsychological performance, followed by an index of presumed hypoxic insults. The effect sizes betweenPPCSand cognitive factors at age 7 were consistently largest with perceptual-motor abilities, followed by academic achievement skills and verbal-conceptual abilities. Future studies will evaluate the effects of specificPPCSand genetic risk factors for psychosis on cognitive functioning in childhood. |