| 1 | Schizophr. Res. 2015 Oct 168: 444-9 |
|---|---|
| PMID | 26324334 |
| Title | Population-dependent contribution of the major histocompatibility complex region to schizophrenia susceptibility. |
| Abstract | There is consistent data from European cohorts suggesting a genetic contribution from the major histocompatibility complex (MHC) to the pathogenesis ofschizophrenia. However, the genomic complexity and ethnicity-specific diversity found in the MHC cause difficulties in identifying causal variants or genes, and there is a need for studies encompassing the entire MHC region in multiple ethnic populations. Here, we report on association signals in the MHC region, withschizophreniain the Japanese population. We genotyped and imputed a total of 10,131 single nucleotide polymorphisms (SNPs), spanning the entire MHC interval. The analysis included 3302 participants (1518schizophrenics and 1784 healthy controls) from the Japanese population. In this study, we present evidence for association at rs494620, located in theSLC44A4gene. The association survived after correction for multiple testing (unadjusted P=7.78�10(-5), empirical P=0.0357). The imputation results detected the highest association at rs707937 in the MSH5-SAPCD1 gene (imputed P=8.40�10(-5)). In expression analysis using postmortem brains fromschizophreniaand control samples, MSH5-SAPCD1 showed marginally significant expression differences in Brodmann's area 46 (P=0.044 by unpaired t test with Welch's correction, P=0.099 by Mann-Whitney U test). Our study further strengthens evidence for the involvement of the MHC inschizophrenia在人群中,nd provides insight into population-specific mechanisms for the MHC region inschizophreniasusceptibility. |
| SCZ Keywords | schizophrenia, schizophrenics |
| 2 | Schizophr. Res. 2015 Oct 168: 444-9 |
| PMID | 26324334 |
| Title | Population-dependent contribution of the major histocompatibility complex region to schizophrenia susceptibility. |
| Abstract | There is consistent data from European cohorts suggesting a genetic contribution from the major histocompatibility complex (MHC) to the pathogenesis ofschizophrenia. However, the genomic complexity and ethnicity-specific diversity found in the MHC cause difficulties in identifying causal variants or genes, and there is a need for studies encompassing the entire MHC region in multiple ethnic populations. Here, we report on association signals in the MHC region, withschizophreniain the Japanese population. We genotyped and imputed a total of 10,131 single nucleotide polymorphisms (SNPs), spanning the entire MHC interval. The analysis included 3302 participants (1518schizophrenics and 1784 healthy controls) from the Japanese population. In this study, we present evidence for association at rs494620, located in theSLC44A4gene. The association survived after correction for multiple testing (unadjusted P=7.78�10(-5), empirical P=0.0357). The imputation results detected the highest association at rs707937 in the MSH5-SAPCD1 gene (imputed P=8.40�10(-5)). In expression analysis using postmortem brains fromschizophreniaand control samples, MSH5-SAPCD1 showed marginally significant expression differences in Brodmann's area 46 (P=0.044 by unpaired t test with Welch's correction, P=0.099 by Mann-Whitney U test). Our study further strengthens evidence for the involvement of the MHC inschizophrenia在人群中,nd provides insight into population-specific mechanisms for the MHC region inschizophreniasusceptibility. |
| SCZ Keywords | schizophrenia, schizophrenics |