| 1 | PLoS ONE 2011 -1 6: e28929 |
|---|---|
| PMID | 22205981 |
| Title | A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population. |
| Abstract | Using a knock-out mouse model, it was shown thatNETO1is a critical component of the NMDAR complex, and that loss ofNETO1leads to impaired hippocampal long term potentiation and hippocampal-dependent learning and memory. Moreover, hemizygosity ofNETO1was shown to be associated with autistic-like behavior in humans. We examined the association betweenschizophreniaand the neuropilin and tolloid-like 1 gene (NETO1). First, we selected eight single nucleotide polymorphisms (SNPs) within theNETO1locus, based on the Japaneseschizophreniagenome wide association study (JGWAS) results and previously conducted association studies. These SNPs were genotyped in the replication sample comprised of 963schizophrenicpatients and 919 healthy controls. We also examined the effect of associated SNPs on scores in the Continuous Performance Test and the Wisconsin Card Sorting Test Keio version (schizophrenic患者107年健康对照组104)。 There were no significant allele-wise and haplotype-wise associations in the replication analysis after Bonferroni correction. However, in meta-analysis (JGWAS and replication dataset) three association signals were observed (rs17795324: p?=?0.028, rs8098760: p?=?0.017, rs17086492: p?=?0.003). These SNPs were followed up but we could not detect the allele-specific effect on cognitive performance measured by the Continuous performance test (CPT) and Wisconsin Card Sorting test (WCST). We did not detect evidence for the association ofNETO1withschizophreniain the Japanese population. Common variants within theNETO1locus may not increase the genetic risk forschizophreniain the Japanese population. Additionally, common variants investigated in the current study did not affect cognitive performance, as measured by the CPT and WCST. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 2 | PLoS ONE 2011 -1 6: e28929 |
| PMID | 22205981 |
| Title | A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population. |
| Abstract | Using a knock-out mouse model, it was shown thatNETO1is a critical component of the NMDAR complex, and that loss ofNETO1leads to impaired hippocampal long term potentiation and hippocampal-dependent learning and memory. Moreover, hemizygosity ofNETO1was shown to be associated with autistic-like behavior in humans. We examined the association betweenschizophreniaand the neuropilin and tolloid-like 1 gene (NETO1). First, we selected eight single nucleotide polymorphisms (SNPs) within theNETO1locus, based on the Japaneseschizophreniagenome wide association study (JGWAS) results and previously conducted association studies. These SNPs were genotyped in the replication sample comprised of 963schizophrenicpatients and 919 healthy controls. We also examined the effect of associated SNPs on scores in the Continuous Performance Test and the Wisconsin Card Sorting Test Keio version (schizophrenic患者107年健康对照组104)。 There were no significant allele-wise and haplotype-wise associations in the replication analysis after Bonferroni correction. However, in meta-analysis (JGWAS and replication dataset) three association signals were observed (rs17795324: p?=?0.028, rs8098760: p?=?0.017, rs17086492: p?=?0.003). These SNPs were followed up but we could not detect the allele-specific effect on cognitive performance measured by the Continuous performance test (CPT) and Wisconsin Card Sorting test (WCST). We did not detect evidence for the association ofNETO1withschizophreniain the Japanese population. Common variants within theNETO1locus may not increase the genetic risk forschizophreniain the Japanese population. Additionally, common variants investigated in the current study did not affect cognitive performance, as measured by the CPT and WCST. |
| SCZ Keywords | schizophrenia, schizophrenic |