| 1 | Biol. Psychiatry 2008 Mar 63: 441-8 |
|---|---|
| PMID | 18179784 |
| Title | MEGF10 association with schizophrenia. |
| Abstract | The 5q21-31 region has been implicated as harboring risk genes forschizophreniain many linkage studies. In our previous report of stepwise fine mapping of this region, theMEGF10gene was one of the genes showing consistent associations in our screening subsample. In this study, we carried out independent replication and expression studies of theMEGF10gene. Association studies with 8 SNPs in theMEGF10gene were performed in the Irish case-control study ofschizophrenia(ICCSS) sample (652 case and 617 control subjects). The expression ofMEGF10was also compared between healthy control subjects andschizophreniapatients using postmortem brain cDNA libraries. In the ICCSS sample, associations with the disease were found in the same risk alleles and haplotypes as that observed in our fine-mapping studies. The major allele (A) of rs27388 was overrepresented in affected individuals (p = .0169), which remained significant after correction for multiple testing. In expression studies,MEGF10had higher expression levels in the affected than the unaffected (p = .015).schizophreniapatients with a 1/1 genotype at rs27388 had higher expressions than those patients with 1/2 and 2/2 genotypes (p = .0008). Evidence from both association and expression studies suggests thatMEGF10is likely associated withschizophrenia. The major allele and 1/1 genotype at rs27388 impose higher risks for the disease. |
| SCZ Keywords | schizophrenia |
| 2 | PLoS ONE 2009 -1 4: e6875 |
| PMID | 19721717 |
| Title | Apoptotic engulfment pathway and schizophrenia. |
| Abstract | Apoptosis has been speculated to be involved inschizophrenia. In a previously study, we reported the association of theMEGF10gene with the disease. In this study, we followed the apoptotic engulfment pathway involving theMEGF10, GULP1, ABCA1 and ABCA7 genes and tested their association with the disease. Ten, eleven and five SNPs were genotyped in the GULP1, ABCA1 and ABCA7 genes respectively for the ISHDSF and ICCSS samples. In all 3 genes, we observed nominally significant associations. Rs2004888 at GULP1 was significant in both ISHDSF and ICCSS samples (p = 0.0083 and 0.0437 respectively). We sought replication in independent samples for this marker and found highly significant association (p = 0.0003) in 3 Caucasian replication samples. But it was not significant in the 2 Chinese replication samples. In addition, we found a significant 2-marker (rs2242436 * rs3858075) interaction between the ABCA1 and ABCA7 genes in the ISHDSF sample (p = 0.0022) and a 3-marker interaction (rs246896 * rs4522565 * rs3858075) amongst theMEGF10在可以sa, GULP1 ABCA1基因mple (p = 0.0120). Rs3858075 in the ABCA1 gene was involved in both 2- and 3-marker interactions in the two samples. From these data, we concluded that the GULP1 gene and the apoptotic engulfment pathway are involved inschizophreniain subjects of European ancestry and multiple genes in the pathway may interactively increase the risks to the disease. |
| SCZ Keywords | schizophrenia |
| 3 | Psychiatry Res 2011 Apr 186: 467-8 |
| PMID | 20813413 |
| Title | No association between schizophrenia and rs27388 of the MEGF10 gene in Chinese case-control sample. |
| Abstract | -1 |
| SCZ Keywords | schizophrenia |