| 1 | Schizophr. Res. 2008 Apr 101: 67-75 |
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| PMID | 18262772 |
| Title | Association of RGS2 and RGS5 variants with schizophrenia symptom severity. |
| Abstract | Several lines of evidence indicate that Regulator of G Protein Signaling 4 (RGS4) contributes toschizophreniavulnerability. RGS4 is one of a family of molecules that modulate signaling via G-protein coupled receptors. Five genes encoding members of this family (RGS2, RGS4, RGS5,RGS8和RGS16)映射到染色体1 q23.3-1q31。由于阿verlapping cellular functions and chromosomal proximity, we hypothesized that multiple RGS genes may contribute toschizophreniaseverity and treatment responsiveness. Subjects were 750 individuals withschizophreniawho participated in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). Inferred ancestries were: 221 (30%) 'Africa only', 422 (56%) 'Europe only' and 107 (14%) 'Other'. Fifty-nine single nucleotide polymorphisms (SNPs) in or near the RGS5, RGS16,RGS8and RGS2 genes were genotyped. Multiple linear regression was used to analyze association of markers with Positive and Negative Symptoms Scale (PANSS) total scores at baseline and throughout antipsychotic treatment. RGS5 marker rs10799902 was associated with altered baseline PANSS total score in both the Africa only (P=0.0440) and Europe only (P=0.0143) strata, although neither association survived multiple comparisons correction. A common five-marker haplotype of the RGS2 gene was associated with more severe baseline PANSS total score in the Europe only strata (global P=0.0254; haplotype-specific P=0.0196). In contrast to RGS4, none of the markers showed association with antipsychotic treatment response. RGS2 and RGS5 genotypes predicted severity of baseline symptoms inschizophrenia. Although these analyses are exploratory and replication is required, these data suggest a possible role for multiple RGS proteins inschizophrenia. |
| SCZ Keywords | schizophrenia |