| Abstract |
TheMPZL1/PZR gene has been mapped to 1q23.3, located in close proximity to a recognizedschizophreniasusceptibility locus. Recently, theMPZL1/PZR gene has been found to be significantly upregulated inschizophrenia大脑组织并发挥重要role in cell signaling, thus indicating thatMPZL1/PZR could be a potentialschizophreniamarker. To test this hypothesis, we selected three single nucleotide polymorphisms (SNPs) for genotyping in 523 Han Chinese trios. We found that two individual SNPs were significant at the Bonferroni's corrected significance level P<0.017: rs3767444 (chi2=6.299, P=0.0121) and rs2051656 (chi2=9.856, P=0.0017). Haplotype transmission/disequilibrium tests revealed a significant association with the disease (global P-value=1.064 x 10(-6)), but no specific transmission distortions. Thus, we propose that theMPZL1/PZR gene may be important in the predisposition toschizophreniaamong Han Chinese. |