| 1 | Int. J. Neuropsychopharmacol. 2015 Feb 18: -1 |
|---|---|
| PMID | 25522406 |
| Title | Schizophrenia gene expression profile reverted to normal levels by antipsychotics. |
| Abstract | Despite the widespread use of antipsychotics, little is known of the molecular bases behind the action of antipsychotic drugs. A genome-wide study is needed to characterize the genes that affect the clinical response and their adverse effects. Here we show the analysis of the blood transcriptome of 22schizophreniapatients before and after medication with atypical antipsychotics by next-generation sequencing. We found that 17 genes, among the 21 495 genes analyzed, have significantly-altered expression after medication (p-value adjusted [Padj] <0.05). Six genes (ADAMTS2CD177 CNTNAP3,ENTPD2, RFX2, and UNC45B) out of the 17 are among the 200 genes that we characterized with differential expression in a previous study between antipsychotic-na�veschizophreniapatients and controls (Sainz et al., 2013). This number ofschizophrenia-altered expression genes is significantly higher than expected by chance (Chi-test, Padj 1.19E-50), suggesting that at least part of the antipsychotic beneficial effects is exerted by modulating the expression of these genes. Interestingly, all six of these genes were overexpressed in patients and reverted to control levels of expression after treatment. We also found a significant enrichment of genes related to obesity and diabetes, known adverse affects of antipsychotics. These results may facilitate understanding of unknown molecular mechanisms behindschizophreniasymptoms and the molecular mechanisms of antipsychotic drugs. |
| SCZ Keywords | schizophrenia |