| 1 | Biol. Psychiatry 2002 Nov 52: 874-9 |
|---|---|
| PMID | 12399140 |
| Title | Elevated expression of integrin alpha(IIb) beta(IIIa) in drug-na�ve, first-episode schizophrenic patients. |
| Abstract | Patients withschizophrenia有风险增加/ t吗he general public of developing cardiovascular illness. It is unknown if there are functional changes in platelet surface receptors inschizophrenia. We therefore analyzed the surface expression of glycoprotein (GP)Ib, the integrin receptor alpha(IIb)beta(IIIa), CD62 (P-selectin), andCD63, and investigated platelet function inschizophrenicpatients compared with healthy volunteers. Nineteen drug-naive, first-episode patients with a DSM IV diagnosis of paranoidschizophreniawere compared with matched healthy controls. Flow cytometry was used to assess platelet surface expression levels of GPIb, alpha(IIb)beta(IIIa), CD62, andCD63. Adenosine diphosphate-induced platelet aggregation was assayed. Theschizophrenicpatients had a significantly (p < .0001) increased number of 68,145 +/- 8,260.1 alpha(IIb)beta(IIIa) receptors, platelet compared with 56,235 +/- 8,079.4 receptors, platelet in healthy controls. Patients withschizophreniahave increased platelet expression of alpha(IIb)beta(IIIa), which may contribute to their increased risk of cardiovascular illness compared with the general population. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 2 | Biol. Psychiatry 2002 Nov 52: 874-9 |
| PMID | 12399140 |
| Title | Elevated expression of integrin alpha(IIb) beta(IIIa) in drug-na�ve, first-episode schizophrenic patients. |
| Abstract | Patients withschizophrenia有风险增加/ t吗he general public of developing cardiovascular illness. It is unknown if there are functional changes in platelet surface receptors inschizophrenia. We therefore analyzed the surface expression of glycoprotein (GP)Ib, the integrin receptor alpha(IIb)beta(IIIa), CD62 (P-selectin), andCD63, and investigated platelet function inschizophrenicpatients compared with healthy volunteers. Nineteen drug-naive, first-episode patients with a DSM IV diagnosis of paranoidschizophreniawere compared with matched healthy controls. Flow cytometry was used to assess platelet surface expression levels of GPIb, alpha(IIb)beta(IIIa), CD62, andCD63. Adenosine diphosphate-induced platelet aggregation was assayed. Theschizophrenicpatients had a significantly (p < .0001) increased number of 68,145 +/- 8,260.1 alpha(IIb)beta(IIIa) receptors, platelet compared with 56,235 +/- 8,079.4 receptors, platelet in healthy controls. Patients withschizophreniahave increased platelet expression of alpha(IIb)beta(IIIa), which may contribute to their increased risk of cardiovascular illness compared with the general population. |
| SCZ Keywords | schizophrenia, schizophrenic |