| Abstract |
The cytomatrix active zone (CAZ) is a specialized cellular structure regulating release of vesicles. We reported previously increased expression of three CAZ genes, piccolo, RIMS2 andRIMS3in the amygdala inschizophrenia。This study determined the levels of gene and protein expression for components of the active zone including two additional CAZ genes in the amygdala from subjects withschizophreniaand non-psychiatric controls, as well as the effects of antipsychotic drugs. Whilst relative real-time PCR analysis did not identify significant change in the expression of six additional active zone genes, Western blot analysis showed increased piccolo and RIMS2 protein expression in the amygdala inschizophrenia。In vitro analysis suggests antipsychotic drug treatment was unlikely to have caused the changes in RIMS2,RIMS3and piccolo expression observed in the amygdala inschizophrenia。因此,这项研究提供了进一步的evidence suggesting that piccolo, RIMS2,RIMS3, but not the entire components of the active zone are involved in the neurobiology ofschizophrenia。 |