肺动脉高血压知识库(bioinfom_tsdb)
bioinfom_tsdb
肺动脉高血压知识库
一般信息|文学|表达式|监管|变体|交互

基本信息

基因身份证

7476年

的名字

WNT7A

同义的

wingless-type MMTV集成网站家庭成员7;WNT7A; wingless-type MMTV集成网站的家庭,成员7

定义

蛋白质Wnt-7a |原癌基因Wnt7a蛋白质

位置

3 p25

基因型

蛋白质编码

突变简介:

 域的突变
在17个主要癌症突变模式
LoF vs错义突变
数据库V72宇宙的所有拷贝数变化
宇宙的所有突变数据库V72

突变总结蛋白质域

前
我们使用从合奏BioMart uniprot蛋白质结构数据的数据库。圆的大小显示了相对变异数。

非同义(上)和(底部)同义突变比例对各种癌症

前
非同义突变模式在17个主要的癌症类型。
同义突变模式在17个主要的癌症类型。

损失函数的突变与错义突变

前
损失函数的突变比较错义突变。
丧失突变在错义突变的比例是0.10。

各种癌症的拷贝数变化

前
拷贝数变化的17个主要癌症组:1;乳腺癌、2;中枢神经系统,3;子宫颈,4;子宫内膜,5;lymphoid_tissue造血,6;肾脏,7;大肠,8;肝脏,9;肺癌、10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

拷贝数变化的17个主要的癌症类型:1;乳腺癌、2;中枢神经系统,3;子宫颈,4;子宫内膜,5;lymphoid_tissue造血,6;肾脏,7;大肠,8;肝脏,9;肺癌、10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

宇宙体细胞突变(最高)

突变(cd;AA;科)

网站

组织学

突变类型

c.873C > T;p.G291G;3:13819121 - 13819121

 骨 Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour 替换-编码沉默

c.241C > T;p.R81C;3:13875004 - 13875004

 large_intestine;盲肠 癌;腺癌 替换-错义

c.150G > C;p.A50A;3:13875095 - 13875095

 皮肤 malignant_melanoma 替换-编码沉默

c.1032G >;p.E344E;3:13818962 - 13818962

 皮肤 malignant_melanoma 替换-编码沉默

c.706G >;p.V236I;3:13819288 - 13819288

 乳房 癌 替换-错义

c.706G >;p.V236I;3:13819288 - 13819288

 乳房 癌 替换-错义

c.314C >;p.A105E;3:13854788 - 13854788

 large_intestine;盲肠 癌;腺癌 替换-错义

c.441G >;p.W147 *;3:13854661 - 13854661

 haematopoietic_and_lymphoid_tissue lymphoid_neoplasm;hairy_cell_leukaemia 替换-胡说

c.441G >;p.W147 *;3:13854661 - 13854661

 NS malignant_melanoma 替换-胡说

c.877G >;p.A293T;3:13819117 - 13819117

 large_intestine;结肠 癌;腺癌 替换-错义

c.921G > T;p.M307I;3:13819073 - 13819073

 肺 癌;squamous_cell_carcinoma 替换-错义

c.476G >;p.G159D;3:13854626 - 13854626

 皮肤 malignant_melanoma 替换-错义

c.231C > T;p.F77F;3:13875014 - 13875014

 皮肤 malignant_melanoma 替换-编码沉默

c.921G > T;p.M307I;3:13819073 - 13819073

 乳房 癌 替换-错义

c.51C >;p.G17G;3:13879766 - 13879766

 肾脏 癌;clear_cell_renal_cell_carcinoma 替换-编码沉默

c.315G >;p.A105A;3:13854787 - 13854787

 乳房 癌 替换-编码沉默

c.315G >;p.A105A;3:13854787 - 13854787

 large_intestine;结肠 癌;腺癌 替换-编码沉默

c.315G >;p.A105A;3:13854787 - 13854787

 large_intestine;结肠 癌;腺癌 替换-编码沉默

c.61C > T;p.L21F;3:13879756 - 13879756

 large_intestine;结肠 癌;腺癌 替换-错义

c.286G >;p.E96K;3:13874959 - 13874959

 皮肤 malignant_melanoma 替换-错义

c.832T >;p.C278S;3:13819162 - 13819162

 NS malignant_melanoma 替换-错义

c.906C > T;p.S302S;3:13819088 - 13819088

 胰腺 癌 替换-编码沉默

c.1038C >;p.Y346 *;3:13818956 - 13818956

 乳房 癌 替换-胡说

c.99C > T;p.G33G;3:13875146 - 13875146

 large_intestine;结肠 癌;腺癌 替换-编码沉默

c.782G >;p.R261H;3:13819212 - 13819212

 large_intestine;结肠 癌;腺癌 替换-错义

c.782G >;p.R261H;3:13819212 - 13819212

 large_intestine 癌;腺癌 替换-错义

c.790A > T;p.M264L;3:13819204 - 13819204

 肺 癌;腺癌 替换-错义

c.123C >;p.I41I;3:13875122 - 13875122

 子宫内膜 癌;endometrioid_carcinoma 替换-编码沉默

c.821C > T;p.S274L;3:13819173 - 13819173

 子宫内膜 癌;endometrioid_carcinoma 替换-错义

c.553A > T;p.N185Y;3:13854549 - 13854549

 胃 癌;腺癌 替换-错义

c.305G > C;p.R102P;3:13854797 - 13854797

 肺 癌;腺癌 替换-错义

c.353C > T;p.A118V;3:13854749 - 13854749

 胃 癌;腺癌 替换-错义

c.595G > C;p.E199Q;3:13819399 - 13819399

 卵巢 癌;serous_carcinoma 替换-错义

c.232C > T;p.R78C;3:13875013 - 13875013

 皮肤 malignant_melanoma 替换-错义

c.907G >;p.G303S;3:13819087 - 13819087

 large_intestine;结肠 癌;腺癌 替换-错义

c.214G >;p.E72K;3:13875031 - 13875031

 urinary_tract;膀胱 癌 替换-错义

c.214G >;p.E72K;3:13875031 - 13875031

 肺 癌;squamous_cell_carcinoma 替换-错义

c.734G >;p.R245H;3:13819260 - 13819260

 胃 癌;腺癌 替换-错义

c.576G >;p.L192L;3:13819418 - 13819418

 肺;middle_lobe 癌;腺癌 替换-编码沉默

c.911G > C;p.C304S;3:13819083 - 13819083

 皮肤;head_neck 癌;squamous_cell_carcinoma 替换-错义

c.889A > C;p.T297P;3:13819105 - 13819105

 皮肤 malignant_melanoma 替换-错义

c.324C > T;p.Y108Y;3:13854778 - 13854778

 前列腺癌 癌;腺癌 替换-编码沉默

c.629C > G;p.T210S;3:13819365 - 13819365

 乳房 癌;basal_ _carcinoma(三阴性) 替换-错义

c.707T > C;p.V236A;3:13819287 - 13819287

 皮肤 malignant_melanoma 替换-错义

c.202A > C;p.M68L;3:13875043 - 13875043

 肺;right_upper_lobe 癌;腺癌 替换-错义

c.387C > T;p.S129S;3:13854715 - 13854715

 骨 Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour 替换-编码沉默

c.502G > T;p.D168Y;3:13854600 - 13854600

 肺 癌;腺癌 替换-错义

c.922T >;p.C308S;3:13819072 - 13819072

 乳房 癌 替换-错义

c.137C > T;p.P46L;3:13875108 - 13875108

 皮肤;head_neck 癌;squamous_cell_carcinoma 替换-错义

c.699C > T;p.N233N;3:13819295 - 13819295

 皮肤 malignant_melanoma 替换-编码沉默

c.977G > T;p.C326F;3:13819017 - 13819017

 肺 癌;腺癌 替换-错义

c.204G > T;p.M68I;3:13875041 - 13875041

 肺;right_upper_lobe 癌;腺癌 替换-错义

c.955G > T;p.A319S;3:13819039 - 13819039

 肺 癌;腺癌 替换-错义

c.1013C > T;p.T338M;3:13818981 - 13818981

 large_intestine;结肠 癌;腺癌 替换-错义

c.1013C > T;p.T338M;3:13818981 - 13818981

 肺 癌;腺癌 替换-错义

c.555C > T;p.N185N;3:13854547 - 13854547

 large_intestine;盲肠 癌;腺癌 替换-编码沉默

c.352G >;p.A118T;3:13854750 - 13854750

 upper_aerodigestive_tract;咽 癌;squamous_cell_carcinoma 替换-错义

c.529_530CG >在;p.R177M;3:13854572 - 13854573

 肺 癌;腺癌 替换-错义

c.555C > T;p.N185N;3:13854547 - 13854547

 食道;lower_third 癌;腺癌 替换-编码沉默

c.304C > T;p.R102W;3:13854798 - 13854798

 皮肤 malignant_melanoma 替换-错义

c.304C > T;p.R102W;3:13854798 - 13854798

 胃 癌;腺癌 替换-错义

c.1041G >;p.T347T;3:13818953 - 13818953

 胰腺 癌 替换-编码沉默

c.788C > T;p.P263L;3:13819206 - 13819206

 皮肤 malignant_melanoma 替换-错义

c.155G > C;p.C52S;3:13875090 - 13875090

 肺 癌;small_cell_carcinoma 替换-错义

c.1025G >;p.R342H;3:13818969 - 13818969

 肝 癌 替换-错义

c.526G > T;p.A176S;3:13854576 - 13854576

 肺 癌;squamous_cell_carcinoma 替换-错义

c.100G >;p.A34T;3:13875145 - 13875145

 large_intestine;结肠 癌;腺癌 替换-错义

c.474C > T;p.Y158Y;3:13854628 - 13854628

 食管 癌;腺癌 替换-编码沉默

c.459T > C;p.S153S;3:13854643 - 13854643

 large_intestine;结肠 癌;腺癌 替换-编码沉默

c.459T > C;p.S153S;3:13854643 - 13854643

 urinary_tract;膀胱 癌 替换-编码沉默

c.171C > T;p.D57D;3:13875074 - 13875074

 子宫内膜 癌;endometrioid_carcinoma 替换-编码沉默

c.667G > T;p.E223 *;3:13819327 - 13819327

 肺;right_upper_lobe 癌;腺癌 替换-胡说

c.724C > T;p.R242C;3:13819270 - 13819270

 子宫内膜 癌;endometrioid_carcinoma 替换-错义

c.492G > T;p.K164N;3:13854610 - 13854610

 肺;right_lower_lobe 癌;腺癌 替换-错义

c.226C > T;p.Q76 *;3:13875019 - 13875019

 urinary_tract;膀胱 癌 替换-胡说

c.600T > G;p.C200W;3:13819394 - 13819394

 large_intestine;结肠 癌;腺癌 替换-错义

c.984C > T;p.F328F;3:13819010 - 13819010

 乳房 癌 替换-编码沉默

c.984C > T;p.F328F;3:13819010 - 13819010

 皮肤 malignant_melanoma 替换-编码沉默

c.299-4G >;p。?。3:13854807 - 13854807

 胰腺 癌 未知的

c.612C > T;p.G204G;3:13819382 - 13819382

 胃 癌;腺癌 替换-编码沉默

c.57C > G;p.V19V;3:13879760 - 13879760

 乳房 癌 替换-编码沉默

c.495C > T;p.V165V;3:13854607 - 13854607

 乳房 癌 替换-编码沉默

c.150G >;p.A50A;3:13875095 - 13875095

 胃 癌;腺癌 替换-编码沉默

c.381C > T;p.N127N;3:13854721 - 13854721

 卵巢 癌;serous_carcinoma 替换-编码沉默

c.822G >;p.S274S;3:13819172 - 13819172

 large_intestine;结肠 癌;腺癌 替换-编码沉默

c.822G >;p.S274S;3:13819172 - 13819172

 large_intestine;直肠 癌;腺癌 替换-编码沉默

c.535C > G;p.L179V;3:13854567 - 13854567

 肺 癌;small_cell_carcinoma 替换-错义

c.623C > T;p.S208L;3:13819371 - 13819371

 皮肤 malignant_melanoma 替换-错义

c.36C > G;p.L12L;3:13879781 - 13879781

 肺 癌;squamous_cell_carcinoma 替换-编码沉默

c.547C > T;p.H183Y;3:13854555 - 13854555

 胃 癌;腺癌 替换-错义

c.679G >;p.V227M;3:13819315 - 13819315

 central_nervous_system;大脑 神经胶质瘤 替换-错义

c.388G >;p.D130N;3:13854714 - 13854714

 乳房 癌 替换-错义

c.268C > T;p.R90C;3:13874977 - 13874977

 胃 癌;intestinal_adenocarcinoma 替换-错义

c.745C > T;p.P249S;3:13819249 - 13819249

 甲状旁腺 腺瘤 替换-错义

c.277T > C;p.F93L;3:13874968 - 13874968

 皮肤 malignant_melanoma 替换-错义

c.639G >;p.T213T;3:13819355 - 13819355

 子宫内膜 癌;endometrioid_carcinoma 替换-编码沉默

c.169G >;p.D57N;3:13875076 - 13875076

 large_intestine;直肠 癌;腺癌 替换-错义

c.989G >;p.W330 *;3:13819005 - 13819005

 皮肤 malignant_melanoma 替换-胡说

c.1046_1047insA;p。* 350 fs ?;3:13818947 - 13818948

 large_intestine;结肠 癌;腺癌 插入——转移

c.513G > T;p.E171D;3:13854589 - 13854589

 卵巢 癌;serous_carcinoma 替换-错义

c.274G >;p.V92I;3:13874971 - 13874971

 large_intestine;结肠 癌;腺癌 替换-错义

c.365C > G;p.A122G;3:13854737 - 13854737

 肺 癌;腺癌 替换-错义

c.511G > T;p.E171 *;3:13854591 - 13854591

 large_intestine;结肠 癌;腺癌 替换-胡说

c.314C > T;p.A105V;3:13854788 - 13854788

 食管 癌;腺癌 替换-错义

c.440G >;p.W147 *;3:13854662 - 13854662

 皮肤;头皮 癌;squamous_cell_carcinoma 替换-胡说

c.273C > G;p.T91T;3:13874972 - 13874972

 肺 癌;腺癌 替换-编码沉默

c.246G >;p.W82 *;3:13874999 - 13874999

 皮肤 malignant_melanoma 替换-胡说

c.246G >;p.W82 *;3:13874999 - 13874999

 皮肤 malignant_melanoma 替换-胡说

c.269G > T;p.R90L;3:13874976 - 13874976

 large_intestine;结肠 癌;腺癌 替换-错义

c.487G >;p.A163T;3:13854615 - 13854615

 large_intestine 癌;腺癌 替换-错义

c.1024C > T;p.R342C;3:13818970 - 13818970

 胃 癌;intestinal_adenocarcinoma 替换-错义

c.1024C > T;p.R342C;3:13818970 - 13818970

 腹膜;附录 其他;pseudomyxoma_peritonei 替换-错义

c.487G >;p.A163T;3:13854615 - 13854615

 large_intestine;结肠 癌;腺癌 替换-错义

c.565C > T;p.R189 *;3:13854537 - 13854537

 皮肤 malignant_melanoma 替换-胡说

c.516C > G;p.I172M;3:13854586 - 13854586

 肺 癌;腺癌 替换-错义

c.687G >;p.K229K;3:13819307 - 13819307

 皮肤 malignant_melanoma 替换-编码沉默

c.463G >;p.D155N;3:13854639 - 13854639

 皮肤 malignant_melanoma 替换-错义

c.180C > T;p.I60I;3:13875065 - 13875065

 皮肤;head_neck 癌;squamous_cell_carcinoma 替换-编码沉默

c.463G >;p.D155N;3:13854639 - 13854639

 子宫内膜 癌;endometrioid_carcinoma 替换-错义

c.469C > T;p.R157C;3:13854633 - 13854633

 皮肤;upper_leg malignant_melanoma 替换-错义

c.853G >;p.G285S;3:13819141 - 13819141

 肺 癌;腺癌 替换-错义

c.340G > T;p.G114C;3:13854762 - 13854762

 卵巢 癌;serous_carcinoma 替换-错义

c.868C >;p.Q290K;3:13819126 - 13819126

 肺 癌;腺癌 替换-错义

c.934G >;p.G312S;3:13819060 - 13819060

 皮肤 malignant_melanoma 替换-错义

c.934G >;p.G312S;3:13819060 - 13819060

 皮肤 malignant_melanoma 替换-错义

c.282delG;p.K95fs * 34;3:13874963 - 13874963

 乳房 癌 删除——转移

c.117C >;p.N39K;3:13875128 - 13875128

 骨 Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour 替换-错义

c.208C > T;p.L70L;3:13875037 - 13875037

 肺 癌;腺癌 替换-编码沉默

c.700G >;p.E234K;3:13819294 - 13819294

 乳房 癌 替换-错义

c.944C > T;p.T315I;3:13819050 - 13819050

 皮肤 malignant_melanoma 替换-错义

c.280G >;p.G94R;3:13874965 - 13874965

 胃 癌;diffuse_adenocarcinoma 替换-错义

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