| 一般信息|文学|表达式|监管|变体|交互 |
基本信息 |
|
|---|---|
基因身份证 |
7538年 |
的名字 |
ZFP36 |
同义的 |
ZFP36无名指蛋白质;ZFP36 ZFP36无名指蛋白质 |
定义 |
G0 / G1开关监管蛋白质24 |增长factor-inducible核NUP475 | tristetraprolin | tristetraproline |锌指蛋白36同族体|锌指蛋白36,影响类型,同族体|锌指蛋白,影响类型,36同族体 |
位置 |
19 q13.1 |
基因型 |
蛋白质编码 |
突变简介: |
域的突变 在17个主要癌症突变模式 LoF vs错义突变 数据库V72宇宙的所有拷贝数变化 宇宙的所有突变数据库V72 |
突变总结蛋白质域 |
前 |
 |
非同义(上)和(底部)同义突变比例对各种癌症 |
前 |
 |
 |
损失函数的突变与错义突变 |
前 |
 |
| 丧失突变在错义突变的比例是0.12。 |
各种癌症的拷贝数变化 |
前 |
 |
拷贝数变化的17个主要的癌症类型:1;乳腺癌、2;中枢神经系统,3;子宫颈,4;子宫内膜,5;lymphoid_tissue造血,6;肾脏,7;大肠,8;肝脏,9;肺癌、10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
宇宙体细胞突变(最高) |
|||
突变(cd;AA;科) |
网站 |
组织学 |
突变类型 |
|---|---|---|---|
c.102C > T;p.S34S;19:39407820 - 39407820 |
皮肤;head_neck | 癌;squamous_cell_carcinoma | 替换-编码沉默 |
c.973T > C;p.S325P;19:39408691 - 39408691 |
central_nervous_system;大脑 | 神经胶质瘤;astrocytoma_Grade_IV | 替换-错义 |
c.15C > T;p.A5A;19:39406919 - 39406919 |
胰腺 | NS | 替换-编码沉默 |
c.730G > T;p.D244Y;19:39408448 - 39408448 |
large_intestine;结肠 | 癌;腺癌 | 替换-错义 |
c.97G >;p.G33S;19:39407815 - 39407815 |
肺 | 癌;腺癌 | 替换-错义 |
c.525G >;p.P175P;19:39408243 - 39408243 |
甲状腺 | 癌 | 替换-编码沉默 |
c.27C > T;p.S9S;19:39407745 - 39407745 |
子宫内膜 | 癌;endometrioid_carcinoma | 替换-编码沉默 |
c.751_752CC TT >;p.P251F;19:39408469 - 39408470 |
皮肤;head_neck | 癌;squamous_cell_carcinoma | 替换-错义 |
c.49G > T;p.V17L;19:39407767 - 39407767 |
皮肤;head_neck | 癌;squamous_cell_carcinoma | 替换-错义 |
c.429G >;p.K143K;19:39408147 - 39408147 |
骨;胫骨 | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | 替换-编码沉默 |
c.857G >;p.S286N;19:39408575 - 39408575 |
large_intestine;结肠 | 癌;腺癌 | 替换-错义 |
c.25-1G > T;p。?。19:39407742 - 39407742 |
肺 | 癌;腺癌 | 未知的 |
c.976G >;p.E326K;19:39408694 - 39408694 |
urinary_tract;膀胱 | 癌 | 替换-错义 |
c.972T > G;p.V324V;19:39408690 - 39408690 |
central_nervous_system;大脑 | 神经胶质瘤;astrocytoma_Grade_IV | 替换-编码沉默 |
c.844G >;p.D282N;19:39408562 - 39408562 |
乳房 | 癌 | 替换-错义 |
c.696C >;p.F232L;19:39408414 - 39408414 |
large_intestine;直肠 | 癌;腺癌 | 替换-错义 |
c.431C > G;p.T144R;19:39408149 - 39408149 |
甲状腺 | 癌 | 替换-错义 |
c.617C > T;p.P206L;19:39408335 - 39408335 |
肺 | 癌;small_cell_carcinoma | 替换-错义 |
c.974C >;p.S325Y;19:39408692 - 39408692 |
central_nervous_system;大脑 | 神经胶质瘤;astrocytoma_Grade_IV | 替换-错义 |
c.535C > T;p.P179S;19:39408253 - 39408253 |
乳房 | 癌 | 替换-错义 |
c.591A > G;p.S197S;19:39408309 - 39408309 |
胃 | 癌;腺癌 | 替换-编码沉默 |
c.189delG;p.G64fs * > 263;19:39407907 - 39407907 |
胰腺 | 癌 | 删除——转移 |
c.172T >;p.S58T;19:39407890 - 39407890 |
皮肤 | malignant_melanoma | 替换-错义 |
c.516G >;p.L172L;19:39408234 - 39408234 |
肺 | 癌;腺癌 | 替换-编码沉默 |
c.181C >;p.L61I;19:39407899 - 39407899 |
乳房 | 癌 | 替换-错义 |
c.971T >;p.V324D;19:39408689 - 39408689 |
central_nervous_system;大脑 | 神经胶质瘤;astrocytoma_Grade_IV | 替换-错义 |
c.62C >;p.S21Y;19:39407780 - 39407780 |
卵巢 | 癌;serous_carcinoma | 替换-错义 |
c.35C >;p.S12 *;19:39407753 - 39407753 |
卵巢 | 其他;肿瘤 | 替换-胡说 |
c.511G > T;p.D171Y;19:39408229 - 39408229 |
肺;right_upper_lobe | 癌;腺癌 | 替换-错义 |
c.14C > T;p.A5V;19:39406918 - 39406918 |
large_intestine | 癌;腺癌 | 替换-错义 |
c.225C > T;p.G75G;19:39407943 - 39407943 |
large_intestine | 癌;腺癌 | 替换-编码沉默 |
c.651C > G;p.S217R;19:39408369 - 39408369 |
乳房 | 癌 | 替换-错义 |
c.713delC;p.L240fs * > 87;19:39408431 - 39408431 |
large_intestine;盲肠 | 癌;腺癌 | 删除——转移 |
c.98G >;p.G33D;19:39407816 - 39407816 |
large_intestine;结肠 | 癌;腺癌 | 替换-错义 |
c.713delC;p.L240fs * > 87;19:39408431 - 39408431 |
large_intestine;结肠 | 癌;腺癌 | 删除——转移 |
c.660A > G;p.P220P;19:39408378 - 39408378 |
large_intestine | 癌;腺癌 | 替换-编码沉默 |
c.660A > G;p.P220P;19:39408378 - 39408378 |
large_intestine | 癌;腺癌 | 替换-编码沉默 |
c.566G >;p.G189D;19:39408284 - 39408284 |
子宫内膜 | 癌;endometrioid_carcinoma | 替换-错义 |
c.405G >;p.Q135Q;19:39408123 - 39408123 |
皮肤;head_neck | 癌;squamous_cell_carcinoma | 替换-编码沉默 |
c.975T >;p.S325S;19:39408693 - 39408693 |
central_nervous_system;大脑 | 神经胶质瘤;astrocytoma_Grade_IV | 替换-编码沉默 |
c.590_592delCAC;p.P201delP;19:39408308 - 39408310 |
large_intestine;直肠 | 癌;腺癌 | 删除——在坐标系 |
c.45T > C;p.P15P;19:39407763 - 39407763 |
肾脏 | 癌;papillary_renal_cell_carcinoma | 替换-编码沉默 |
c.590_592delCAC;p.P201delP;19:39408308 - 39408310 |
large_intestine;盲肠 | 癌;腺癌 | 删除——在坐标系 |
c.590_592delCAC;p.P201delP;19:39408308 - 39408310 |
large_intestine;结肠 | 癌;腺癌 | 删除——在坐标系 |
c.590_592delCAC;p.P201delP;19:39408308 - 39408310 |
large_intestine;盲肠 | 癌;腺癌 | 删除——在坐标系 |
c.413G >;p.R138H;19:39408131 - 39408131 |
upper_aerodigestive_tract;口 | 癌;squamous_cell_carcinoma | 替换-错义 |
c.238G > T;p.A80S;19:39407956 - 39407956 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm;chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | 替换-错义 |
c.13G > T;p.A5S;19:39406917 - 39406917 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm;acute_lymphoblastic_leukaemia | 替换-错义 |
c.400C > T;p.R134C;19:39408118 - 39408118 |
胰腺 | 癌 | 替换-错义 |
c.739C >;p.P247T;19:39408457 - 39408457 |
large_intestine | 癌;腺癌 | 替换-错义 |
c.739C >;p.P247T;19:39408457 - 39408457 |
large_intestine;结肠 | 癌 | 替换-错义 |
c.804G > C;p.L268L;19:39408522 - 39408522 |
肺;right_lower_lobe | 癌;腺癌 | 替换-编码沉默 |
c.130G > T;p.D44Y;19:39407848 - 39407848 |
肺;right_lower_lobe | 癌;腺癌 | 替换-错义 |
c.544C > T;p.R182C;19:39408262 - 39408262 |
肺 | 癌;squamous_cell_carcinoma | 替换-错义 |
c.30C >;p.L10L;19:39407748 - 39407748 |
肺 | 癌;squamous_cell_carcinoma | 替换-编码沉默 |
c.865A > T;p.S289C;19:39408583 - 39408583 |
食管 | 癌 | 替换-错义 |
c.908T > G;p.V303G;19:39408626 - 39408626 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm;acute_myeloid_leukaemia | 替换-错义 |
c.847G > T;p.E283 *;19:39408565 - 39408565 |
large_intestine | 癌;腺癌 | 替换-胡说 |