| 一般信息|文学|表达式|监管|变体|交互 |
基本信息 |
|
|---|---|
基因身份证 |
841年 |
的名字 |
CASP8 |
同义的 |
ALPS2B | CAP4 | Casp-8 | FLICE | |马赫MCH5;半胱天冬酶8日apoptosis-related半胱氨酸肽酶;CASP8;半胱天冬酶8日apoptosis-related半胱氨酸肽酶 |
定义 |
FADD-homologous冰/ CED-3-like蛋白酶| | FADD-like冰像冰一样的凋亡蛋白酶5 | MACH-alpha-1/2/3蛋白质| | MACH-beta-1/2/3/4蛋白质MORT1-associated ced-3同族体|凋亡半胱氨酸蛋白酶|凋亡蛋白酶Mch-5 |半胱天冬酶8日apoptosis-related cystein |
位置 |
2 q33-q34 |
基因型 |
蛋白质编码 |
基因调控: |
上游小分子核糖核酸 转录因子 从dbPTM转录后修饰 甲基化从DiseaseMeth数据库配置文件 |
实验验证了从miRTarBase microrna(最高) |
 |
转录因子(最高) |
从数据库TransFac监管 |
|---|
| proCaspase-8b (h) - - > Caspase-8b-p41 (h) +蛋白质残留(处理) |
| proCaspase-8b (h) - - > Caspase-8b-p18 (h) +蛋白质残留(处理) |
| c-FLIP-R (h) + c-FLIP-L (h) + proCaspase-8b (h) + FADD (h) + Fas (h) < = = > c-FLIP-R (h): c-FLIP-L (h): proCaspase-8b (h): FADD (h): Fas (h)(绑定) |
| c-FLIP-L (h) + proCaspase-8b (h) + Fas (h) < = = > c-FLIP-L (h): proCaspase-8b (h): Fas (h)(绑定) |
| CASP8 (h) - - > proCaspase-8b (h)(表达式)。 |
| CASP8 (h) - - > proCaspase-8c (h)(表达式)。 |
| FADD (h) + proCaspase-8d (h) < = = > FADD (h): proCaspase-8d (h)(绑定) |
| proCaspase-8a (h) + proCaspase-8d (h) < = = > proCaspase-8a (h): proCaspase-8d (h)(绑定) |
| CASP8 (h) - - > proCaspase-8d (h)(表达式)。 |
| CASP8 (h) - - > proCaspase-8e (h)(表达式)。 |
| CASP8 (h) - - > proCaspase-8f (h)(表达式)。 |
| CASP8 (h) - - > proCaspase-8g (h)(表达式)。 |
| c-FLIP-L (h) + proCaspase-8 (h) < = = > c-FLIP-L (h): proCaspase-8 (h)(绑定) |
| c-FLIP-S (h) + proCaspase-8 (h) < = = > c-FLIP-S (h): proCaspase-8 (h)(绑定) |
| Apaf-1 (h) + proCaspase-8 (h) < = = > Apaf-1 (h): proCaspase-8 (h)(绑定) |
| 酒吧(h) + proCaspase-8 (h) < = = >栏(h): proCaspase-8 (h)(绑定) |
| proCaspase-8 (h)——Caspase-6 (h) - - > Caspase-8 (h)(处理) |
| c-FLIP-L-p43 (h) + FADD (h) + Fas (h) + FasL (h) + proCaspase-8 (h) < = = > FasL (h): Fas (h): FADD (h): proCaspase-8 (h): c-FLIP-L-p43 (h)(绑定) |
| Hip-1 (h) + proCaspase-8 (h) < = = > Hip-1 (h): proCaspase-8 (h)(绑定) |
| Hippi (h) + proCaspase-8 (h) < = = > Hippi (h): proCaspase-8 (h)(绑定) |
| p38alpha (h) + proCaspase-8 (h) < = = > p38alpha (h): proCaspase-8 (h)(绑定) |
| p38alpha (h) {p} + proCaspase-8 (h) < = = > p38alpha (h) {p}: proCaspase-8 (h)(绑定) |
| proCaspase-8 (h) + RIP3 (h) < = = > proCaspase-8 (h): RIP3 (h)(绑定) |
| proCaspase-8 (h) - - > Caspase-8-p18 (h) + Caspase-8-p12 (h) +蛋白质残留(处理) |
| proCaspase-8 (h)——Caspase-10 (h) - - > Caspase-8-p43 (h) + Caspase-8-p12 (h) +蛋白质残留(处理) |
| 2 proCaspase-8 (h) < = = > (proCaspase-8 (h)) 2(绑定) |
| proCaspase-8 (h)——Caspase-3 (vs)——>蛋白质残留(处理) |
| Apo2L (h) + proCaspase-8 (h) < = = > Apo2L (h): proCaspase-8 (h)(绑定) |
| FasL (h) + proCaspase-8 (h) < = = > FasL (h): proCaspase-8 (h)(绑定) |
| FAF1 (h) + proCaspase-8 (h) < = = > FAF1 (h): proCaspase-8 (h)(绑定) |
| proCaspase-8 (h) + Fas (h) < = = > Fas (h): proCaspase-8 (h)(绑定) |
| FADD (h) + proCaspase-8 (h) < = = > FADD (h): proCaspase-8 (h)(绑定) |
| proCaspase-8 (h) + FADD(理科硕士)< = = > proCaspase-8 (h): FADD(理科硕士)(绑定) |
| proCaspase-8 (h) + Apo2L (h) + FADD (h) + DR5 (h) < = = > proCaspase-8 (h): Apo2L (h): FADD (h): DR5 (h)(绑定) |
| proCaspase-8 (h) + DEDD(理科硕士)< = = > proCaspase-8 (h): DEDD(理科硕士)(绑定) |
| proCaspase-8 (h) - - > TRADD (h)(绑定) |
| proCaspase-8 (h) - - > FADD (h)(绑定) |
| proCaspase-8 (h) - - > TRAF2 (h)(绑定) |
| proCaspase-8 (h) - - > FAF1(理科硕士)(激活) |
| proCaspase-8 (h) - - > Caspase-8-p43 (h) +蛋白质残留(处理) |
| proCaspase-8 (h) - - > Caspase-8-p41 (h) +蛋白质残留(处理) |
| proCaspase-8 (h) - - > Caspase-8-p18 (h) +蛋白质残留(处理) |
| proCaspase-8 (h) + ATP - - > proCaspase-8 (h) {pY380} + ADP(磷酸化) |
| proCaspase-8 (h) + ATP - - > proCaspase-8 (h) {pY} + ADP(磷酸化) |
| c-FLIP-L-p43 (h) + FADD (h) + Fas (h) + proCaspase-8 (h) < = = > c-FLIP-L-p43 (h): FADD (h): Fas (h): proCaspase-8 (h)(绑定) |
| c-FLIP-L-p43 (h) + FADD (h) + proCaspase-8 (h) + Fas (h) < = = > c-FLIP-L-p43 (h): Fas (h): FADD (h): proCaspase-8 (h)(绑定) |
| Apo2L (h) + DR5 (h) + FADD (h) + proCaspase-8 (h) + c-FLIP-L (h) < = = > Apo2L (h): DR5 (h): FADD (h): proCaspase-8 (h): c-FLIP-L (h)(绑定) |
| Fas (h) + FasL (h) + c-FLIP-S(理科硕士)+ FADD (h) + proCaspase-8 (h) + c-FLIP-L-p43 (h) < = = > Fas (h): FasL (h): c-FLIP-S(理科硕士):FADD (h): proCaspase-8 (h): c-FLIP-L-p43 (h)(绑定) |
| proCaspase-8 (h) + c-FLIP-L(理科硕士)< = = > proCaspase-8 (h): c-FLIP-L(理科硕士)(绑定) |
| FasL (h) + c-FLIP-S(理科硕士)+ proCaspase-8 (h) < = = > FasL (h): proCaspase-8 (h): c-FLIP-S(理科硕士)(绑定) |
| FasL (h) + proCaspase-8 (h) + c-FLIP-L-p43 (h) + c-FLIP-S(理科硕士)+ RIP (h) < = = > FasL (h): proCaspase-8 (h): c-FLIP-L-p43 (h): c-FLIP-S(理科硕士):把(h)(绑定) |
| proCaspase-8 (h) - - > Caspase-8-p16 (h) +蛋白质残留(裂) |
| proCaspase-8 (h)——Caspase-3 (h) - - > Caspase-8-p41 (h) +蛋白质残留(裂) |
| proCaspase-8 (h)——Caspase-6 (h) - - > Caspase-8-p41 (h) +蛋白质残留(裂) |
| proCaspase-8 (h)——Caspase-3 (h) - - > Caspase-8-p43 (h) +蛋白质残留(裂) |
| proCaspase-8 (h)——Caspase-6 (h) - - > Caspase-8-p43 (h) +蛋白质残留(裂) |
| Apo2L(理科硕士)+ proCaspase-8 (h) < = = > Apo2L(理科硕士):proCaspase-8 (h)(绑定) |
| proCaspase-8 (h) - - > Caspase-8-p26 (h) +蛋白质残留(裂) |
| proCaspase-8 (h) + FADD (h) + RIP (h) + c-FLIP-L (h) < = = > proCaspase-8 (h): FADD (h):把(h): c-FLIP-L (h)(绑定) |
| proCaspase-8 (h) + FADD (h) + RIP (h) + c-FLIP-L (h) + c-FLIP-S (h) < = = > proCaspase-8 (h): FADD (h):把(h): c-FLIP-L (h): c-FLIP-S (h)(绑定) |
| Fas (h) + FADD (h) + proCaspase-8 (h) + c-FLIP-p22(理科硕士)< = = > Fas (h): FADD (h): proCaspase-8 (h): c-FLIP-p22(理科硕士)(绑定) |
| Fas (h) + proCaspase-8 (h) + Caspase-2-p33 (h) < = = > Fas (h): proCaspase-8 (h): Caspase-2-p33 (h)(绑定) |
| Fas (h) + proCaspase-2 (h) + proCaspase-8 (h) < = = > Fas (h): proCaspase-2 (h): proCaspase-8 (h)(绑定) |
| proCaspase-8 (h)——Caspase-3(理科硕士)——> Caspase-8-p43 (h) +蛋白质残留(裂) |
| proCaspase-8 (h)——Caspase-3(理科硕士)——> Caspase-8-p41 (h) +蛋白质残留(裂) |
| proCaspase-8 (h) + GMEB-1 (h) < = = > proCaspase-8 (h): GMEB-1 (h)(绑定) |
| Fas (h) + FADD (h) + proCaspase-8 (h) < = = > Fas (h): FADD (h): proCaspase-8 (h)(绑定) |
| proCaspase-8 (h) - - > Caspase-8-p53 (h) +蛋白质残留(裂) |
| proCaspase-8 (h) - - >蛋白质残留(处理) |
| proCaspase-8 (h) - - > Caspase-8-p44 (h) +蛋白质残留(处理) |
| Fas (h) + proCaspase-8 (h) + FADD (h) < = = > Fas (h): proCaspase-8 (h): FADD (h)(绑定) |
| proCaspase-8 (h) + FADD (h) < = = > proCaspase-8 (h): FADD (h)(绑定) |
| RIP(理科硕士)+ proCaspase-8 (h) < = = > RIP(理科硕士):proCaspase-8 (h)(绑定) |
| proCaspase-8 (h) - - > Caspase-8-p40 (h) +蛋白质残留(处理) |
| proCaspase-8 (h) - - > Caspase-8-p17 (h) +蛋白质残留(处理) |
| proCaspase-8 (h) - - > Caspase-8-p20 (h) +蛋白质残留(处理) |
| proCaspase-8 (h) - - > Caspase-8-p42 (h) +蛋白质残留(处理) |
| proCaspase-8 (h) + FADD (h) + c-FLIP-L-p43 (h) + c-FLIP-S (h) < = = > proCaspase-8 (h): FADD (h): c-FLIP-L-p43 (h): c-FLIP-S (h)(绑定) |
| FLASH(理科硕士)+ TRAF2 (h) + proCaspase-8 (h) < = = > FLASH(理科硕士):TRAF2 (h): proCaspase-8 (h)(绑定) |
| proCaspase-8 (h) - - > Caspase-8-p28 (h) +蛋白质残留(处理) |
| proCaspase-8 (h) - - > Caspase-8-p45 (h) +蛋白质残留(处理) |
| proCaspase-8 (h) - - > Caspase-8 (h) +蛋白质残留(裂) |
| proCaspase-8 (h) - - > Caspase-8-p23 (h) +蛋白质残留(裂) |
| CASP8 (h) - - > proCaspase-8 (h)(表达式)。 |
| TNFR1 (h) - - > proCaspase-8 (h)(绑定) |
| Apo2L(理科硕士)——> proCaspase-8 (h)(激活) |
| Daxx (h) - - > proCaspase-8 (h)(增加了处理) |
| Fas (h) - - > proCaspase-8 (h)(增加了处理) |
| Apo2L (h) - - > proCaspase-8 (h)(增加了处理) |
| c-FLIP-L(理科硕士)——proCaspase-8 (h) - - > c-FLIP-L-p33(理科硕士)+ c-FLIP-L-p22(理科硕士)(理) |
| FADD (h) + proCaspase-8a (h) < = = > FADD (h): proCaspase-8a (h)(绑定) |
| proCaspase-8a (h) + proCaspase-8d (h) < = = > proCaspase-8a (h): proCaspase-8d (h)(绑定) |
| FADD (vs) + proCaspase-8a (h) < = = > FADD (vs): proCaspase-8a (h)(绑定) |
| proCaspase-8a (h) - - > Caspase-8a-p43 (h) + Caspase-8a-p12 (h)(处理) |
| proCaspase-8a (h)——FasL (h) - - > Caspase-8a-p20 (h) + Caspase-8a-p12 (h) +蛋白质残留(处理) |
| proCaspase-8a (h)——Apo2L (h) - - > Caspase-8a-p20 (h) + Caspase-8a-p12 (h) +蛋白质残留(处理) |
| proCaspase-8a (h) + GMEB1-xbb2 (h) < = = > proCaspase-8a (h): GMEB1-xbb2 (h)(绑定) |
| proCaspase-8a (h) - - > Caspase-8a-p43 (h) +蛋白质残留(处理) |
| proCaspase-8a (h) - - > Caspase-8a-p18 (h) +蛋白质残留(处理) |
| c-FLIP-R (h) + c-FLIP-L (h) + proCaspase-8a (h) + FADD (h) + Fas (h) < = = > c-FLIP-R (h): c-FLIP-L (h): proCaspase-8a (h): FADD (h): Fas (h)(绑定) |
| c-FLIP-L (h) + proCaspase-8a (h) + Fas (h) < = = > c-FLIP-L (h): proCaspase-8a (h): Fas (h)(绑定) |
| CASP8 (h) - - > proCaspase-8a (h)(表达式)。 |
| CASP8 (h) - - > proCaspase-8h (h)(表达式)。 |
| CASP8 (h) - - > proCaspase-8-isoform-3 (h)(表达式)。 |
| CASP8 (h) - - > proCaspase-8-isoform-4 (h)(表达式)。 |
| CASP8 (h) - - > proCaspase-8-isoform-6 (h)(表达式)。 |
| CASP8 (h) - - > proCaspase-8-isoform-9 (h)(表达式)。 |
转录后修饰(最高) |
|||
位置(AA) |
天车类型 |
文学 |
数据库 |
|---|---|---|---|
| 188年 | 磷酸丝氨酸(通过相似)。 | Swiss-Prot 53.0 | |
| 334年 | Phosphotyrosine。 | Swiss-Prot 53.0 | |
| 334年 | Phosphotyrosine | 15592455 | 磷质。榆树6.0 |
| 347年 | 磷酸丝氨酸(MAPK14) | 14970175 | 磷质。榆树6.0 |
甲基化概要(最高) |
||
染色体 |
位置 |
源 |
|---|---|---|
chr2 |
子:201804911 - 201806911 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
子:201804911 - 201806911 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
子:201804911 - 201806911 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
子:201804911 - 201806911 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
子:201804911 - 201806911 | GSE27584 |
chr2 |
子:201829499 - 201831499 | GSE27584 |
chr2 |
子:201804911 - 201806911 | GSE27584 |
chr2 |
子:201804911 - 201806911 | GSE27584 |
chr2 |
子:201804911 - 201806911 | GSE27584 |
chr2 |
子:201829499 - 201831499 | Agilent_014791 |
chr2 |
子:201804911 - 201806911 | PMID: 14688019 |
chr2 |
子:201829499 - 201831499 | PMID: 14688019 |
chr2 |
子:201804911 - 201806911 | PMID: 14688019 |
chr2 |
子:201804911 - 201806911 | PMID: 14688019 |
chr2 |
子:201831968 - 201833968 | PMID: 14688019 |
chr2 |
子:201804911 - 201806911 | PMID: 14688019 |
chr2 |
子:201804911 - 201806911 | PMID: 15029256 |
chr2 |
子:201829499 - 201831499 | PMID: 15029256 |
chr2 |
子:201804911 - 201806911 | PMID: 15029256 |
chr2 |
子:201804911 - 201806911 | PMID: 15029256 |
chr2 |
子:201831968 - 201833968 | PMID: 15029256 |
chr2 |
子:201804911 - 201806911 | PMID: 15029256 |
chr2 |
子:201804911 - 201806911 | PMID: 16688669 |
chr2 |
子:201829499 - 201831499 | PMID: 16688669 |
chr2 |
子:201804911 - 201806911 | PMID: 16688669 |
chr2 |
子:201804911 - 201806911 | PMID: 16688669 |
chr2 |
子:201831968 - 201833968 | PMID: 16688669 |
chr2 |
子:201804911 - 201806911 | PMID: 16688669 |
chr2 |
子:201804911 - 201806911 | PMID: 16616114 |
chr2 |
子:201829499 - 201831499 | PMID: 16616114 |
chr2 |
子:201804911 - 201806911 | PMID: 16616114 |
chr2 |
子:201804911 - 201806911 | PMID: 16616114 |
chr2 |
子:201831968 - 201833968 | PMID: 16616114 |
chr2 |
子:201804911 - 201806911 | PMID: 16616114 |
chr2 |
子:201804911 - 201806911 | PMID: 16051033 |
chr2 |
子:201829499 - 201831499 | PMID: 16051033 |
chr2 |
子:201804911 - 201806911 | PMID: 16051033 |
chr2 |
子:201804911 - 201806911 | PMID: 16051033 |
chr2 |
子:201831968 - 201833968 | PMID: 16051033 |
chr2 |
子:201804911 - 201806911 | PMID: 16051033 |
chr2 |
子:201804911 - 201806911 | PMID: 16983315 |
chr2 |
子:201829499 - 201831499 | PMID: 16983315 |
chr2 |
子:201804911 - 201806911 | PMID: 16983315 |
chr2 |
子:201804911 - 201806911 | PMID: 16983315 |
chr2 |
子:201831968 - 201833968 | PMID: 16983315 |
chr2 |
子:201804911 - 201806911 | PMID: 16983315 |
chr2 |
子:201804911 - 201806911 | PMID: 15365725 |
chr2 |
子:201829499 - 201831499 | PMID: 15365725 |
chr2 |
子:201804911 - 201806911 | PMID: 15365725 |
chr2 |
子:201804911 - 201806911 | PMID: 15365725 |
chr2 |
子:201831968 - 201833968 | PMID: 15365725 |
chr2 |
子:201804911 - 201806911 | PMID: 15365725 |
chr2 |
子:201804911 - 201806911 | PMID: 17272309 |
chr2 |
子:201829499 - 201831499 | PMID: 17272309 |
chr2 |
子:201804911 - 201806911 | PMID: 17272309 |
chr2 |
子:201804911 - 201806911 | PMID: 17272309 |
chr2 |
子:201831968 - 201833968 | PMID: 17272309 |
chr2 |
子:201804911 - 201806911 | PMID: 17272309 |
chr2 |
子:201804911 - 201806911 | PMID: 11709729 |
chr2 |
子:201829499 - 201831499 | PMID: 11709729 |
chr2 |
子:201804911 - 201806911 | PMID: 11709729 |
chr2 |
子:201804911 - 201806911 | PMID: 11709729 |
chr2 |
子:201831968 - 201833968 | PMID: 11709729 |
chr2 |
子:201804911 - 201806911 | PMID: 11709729 |
chr2 |
子:201804911 - 201806911 | PMID: 15788647 |
chr2 |
子:201829499 - 201831499 | PMID: 15788647 |
chr2 |
子:201804911 - 201806911 | PMID: 15788647 |
chr2 |
子:201804911 - 201806911 | PMID: 15788647 |
chr2 |
子:201831968 - 201833968 | PMID: 15788647 |
chr2 |
子:201804911 - 201806911 | PMID: 15788647 |
chr2 |
子:201804911 - 201806911 | PMID: 12826052 |
chr2 |
子:201829499 - 201831499 | PMID: 12826052 |
chr2 |
子:201804911 - 201806911 | PMID: 12826052 |
chr2 |
子:201804911 - 201806911 | PMID: 12826052 |
chr2 |
子:201831968 - 201833968 | PMID: 12826052 |
chr2 |
子:201804911 - 201806911 | PMID: 12826052 |
chr2 |
子:201804911 - 201806911 | PMID: 17064406 |
chr2 |
子:201829499 - 201831499 | PMID: 17064406 |
chr2 |
子:201804911 - 201806911 | PMID: 17064406 |
chr2 |
子:201804911 - 201806911 | PMID: 17064406 |
chr2 |
子:201831968 - 201833968 | PMID: 17064406 |
chr2 |
子:201804911 - 201806911 | PMID: 17064406 |
chr2 |
子:201804911 - 201806911 | PMID: 12433278 |
chr2 |
子:201829499 - 201831499 | PMID: 12433278 |
chr2 |
子:201804911 - 201806911 | PMID: 12433278 |
chr2 |
子:201804911 - 201806911 | PMID: 12433278 |
chr2 |
子:201831968 - 201833968 | PMID: 12433278 |
chr2 |
子:201804911 - 201806911 | PMID: 12433278 |
chr2 |
子:201804911 - 201806911 | PMID: 12632081 |
chr2 |
子:201829499 - 201831499 | PMID: 12632081 |
chr2 |
子:201804911 - 201806911 | PMID: 12632081 |
chr2 |
子:201804911 - 201806911 | PMID: 12632081 |
chr2 |
子:201831968 - 201833968 | PMID: 12632081 |
chr2 |
子:201804911 - 201806911 | PMID: 12632081 |
chr2 |
子:201804911 - 201806911 | PMID: 14555992 |
chr2 |
子:201829499 - 201831499 | PMID: 14555992 |
chr2 |
子:201804911 - 201806911 | PMID: 14555992 |
chr2 |
子:201804911 - 201806911 | PMID: 14555992 |
chr2 |
子:201831968 - 201833968 | PMID: 14555992 |
chr2 |
子:201804911 - 201806911 | PMID: 14555992 |