阿迪比博士beplay苹果手机能用吗研究包括生物医学研究,包括解决颞下颌疾病(TMD),口面疼痛和夜间磨牙症(牙齿夜间研磨)的诊断挑战和治疗选择的设备。
Chiquet博士research focuses on studying the genetics of craniofacial development, with emphasis on cleft lip and palate. He has shown that the CRISPLD2 gene has been shown to be associated with nonsyndromic cleft lip and palate and critical for normal palate and jaw formation in zebrafish. Pathway analysis is underway testing for association with differentially regulated genes in the presence or absence of CRISPLD2 in zebrafish. Additionally, his lab is looking at a known pathway of development, the β-catenin mediated WNT pathway, to determine if these genes are involved in clefting etiology. Other ongoing projects include (1) studying genetic modifiers of cleft lip and palate phenotype, (2) evaluating the microbiome of patients born with cleft lip and palate, (3) analyzing dental materials used in presurgical appliance therapy for children born with cleft lip and palate, and (4) minimizing exposure of general anesthesia for children undergoing dental rehabilitation under general anesthesia.
Fakhouri博士beplay苹果手机能用吗研究兴趣的重点是识别引起并导致增加颅面疾病风险在内的表观遗传因素和遗传因素,包括唇裂和pa裂,颅骨症和微知。他的实验室使用小鼠模型和器官培养物来描述两个转录因子之间的新遗传相互作用的分子机制,即IRF6和Twist1,在调节口腔,面部和颅骨发育过程中调节上皮 - 间质相互作用方面起着至关重要的作用。使用生化和遗传方法,他的实验室研究了Twist1磷酸化点中的突变如何破坏源自间充质细胞的颅面组织的形成。Fakhouri的实验室还利用了开发计算模型的实验数据和生物信息学的整合来鉴定与癌症疾病有关的病因学非编码DNA变异,包括头颈鳞状癌。他的实验室研究的总体目标是将其基准调查结果转化为诊所,以beplay苹果手机能用吗改善风险评估并为个性化医学铺平道路。
Hecht博士has two research focuses. Genes contributing to nonsyndromic cleft lip and palate are identified using next generation sequencing in a family-based approach, and then functionally tested in zebrafish. This approach has successfully identified genes that are now being modeled in mice. In our cartilage biology studies, a DOX-inducible mouse (MT-COMP) with the common COMP mutation was used to delineate the chondrocyte-specific mechanisms causing the dwarfing condition, pseudoachondroplasia. We have successfully tested different treatments in the MT-COMP mouse, which partially rescued the short limb phenotype.
Dr. Iwata’sbeplay苹果手机能用吗研究重点是理解引起颅面先天缺陷和口腔疾病的机制。他的小组试图确定1)胞吐和自噬的作用,2)非编码RNA,3)细胞胆固醇代谢,以及4)Wnt信号传导途径在颅面发育和稳态中。他们已经生成了新的遗传小鼠模型,并一直使用包括遗传学,基因组学,蛋白质组学和生物信息学在内的多学科方法来表征分子机制。他的小组试图确定新的治疗剂和新的诊断工具的新目标,以识别风险人群中的缺陷和疾病。
卡斯珀博士research applies fundamentals of engineering, materials science, and the biosciences toward the development and evaluation of biomaterial-based technologies to meet clinical needs. Current research interests include the application of engineered culture conditions for the development of bioactive constructs for craniofacial and orthopedic tissue regeneration. Additional research focuses on applications of 3D printing and digital technologies in dentistry.
Noriaki Ono博士research focuses on the fundamental biology of skeletal stem cells, with a further scope on understanding pathophysiology of dental, craniofacial and skeletal deformities and diseases that affect millions of children and adults.
Wanida Ono博士research focuses on the fundamental biology of dental development and tooth eruption, with a further scope on understanding signaling pathways and molecular mechanism involving in these processes.
莱特拉博士beplay苹果手机能用吗研究重点是鉴定有助于复杂口腔特征的遗传变异,包括颅面异常和口腔炎症条件。她的小组目前正在研究人类中唇裂/pa,牙齿异常和根尖疾病的基因发现研究,并进一步探索已鉴定基因在这些疾病的细胞和/或动物模型中的作用。最近,她的研究开始探索颅面异常与癌症以beplay苹果手机能用吗及口腔健康系统健康相关性之间的潜在相关性。
席尔瓦博士beplay苹果手机能用吗研究重点是描述颅面异常的遗传学和根本疾病遗传易感性的两个不同的项目(一种与颌骨骨质流失有关的慢性炎症过程)。我们正在检验以下假设:癌症和先天性畸形具有共同的病因。该项目的初步数据显示,有几种类型的癌症,尤其是结肠癌,颅面异常的个体/家庭,例如牙齿发育不全,唇lip和paple。Gene Discovery研究表明AXIN2是WNT途径的负调节剂,是非综合性口服裂口的潜在候选基因。
Dr. Wonghas two major research interests. Within the AFIRM consortium, his project focuses on the management of severe maxillofacial injuries through a series of therapeutic interventions. First, preservation of skeletal space is accomplished with a drug-eluting methylmethacrylate polymer. This is followed by the generation of customized vascularized bone grafts formed in a distant site and subsequently transferred into the traumatic defect. His second research focus involves the characterization of TMJ disease and the regeneration of the disc and condyle using tissue engineering principles.