The University of Texas MD Anderson Cancer Center
Department of Clinical Cancer Prevention

Cancer genome sequencing studies reveal that cancer result in large part from the accumulation of genetic alterations. The progression of premalignant cells is an evolutionary process in which genomic instability provides the fundamental driving force for genetic diversity. Thus, the overall goal of my laboratory is to apply the basic knowledge of genome maintenance mechanisms to cancer prevention and therapy. More specifically, recent work in my laboratory explores the following directions.

1. Identify genetic alterations in the DNA repair network that occur at early stage of carcinogenesis
   我们旨在研究染色质重塑复合物SWI/SNF的新功能，人核酸酶/解旋酶DNA2和突变酶Apobec3b在促进肿瘤发生的两者中促进肿瘤发生体外and体内studies, which may lead to identification of new strategies for early detection and intervention.

2. Discover novel agents targeting the DNA repair network by genetic and chemical approaches
   我们旨在利用化学筛查和生物信息学的工具作为我们的药物发现平台，以系统地识别针对DNA修复网络的化学化合物。我们将确定特定DNA修复途径的调节是否会导致具有多动态DNA复制以及BRCA-和不匹配修复缺陷的细胞中的合成致死性相互作用。这些候选化合物将测试其癌症预防和治疗作用。

3. Develop systems biology approaches to understand the dynamics of the DNA repair network in tumor evolution
   We aim to utilize network-based mathematical modeling and molecular biology approaches to understand and target the DNA repair network. These new interdisciplinary approaches will offer a revolutionary conceptual framework to determine the compound effect of the DNA repair network rather than focusing on an individual repair gene’s function in tumorigenesis.

PubMed

MDACC Faculty

教育和培训

M.D. - Tongji Medical University - 2002
Ph.D. - University of South Carolina - 2005

Research Opportunities

• Seeking MS Students
• Seeking PhD Students

Programs

• Genetics and Epigenetics