临床试验调查高剂量是否vitamin D3 supplements combined with a multivitamin could effectively prevent cluster headaches is now recruiting patients at The University of Texas Health Science Center at Houston (UthealthHouston）。

这项研究，由马克·伯里什（Mark Burish），医学博士，博士，维维安·史密斯（Vivian L. Smith）神经外科助理教授与休斯敦Uthealth的麦戈文医学院（McGovern Medical School）的启发，其灵感来自Cluster Busters的反馈，这是一个患者经营的社区支持小组，其成员遭受了群集头痛攻击。

伯里什说：“群集克星小组的成员已经为其他医疗问题服用了高剂量的维生素D补充剂，并说它为他们的集群头痛起作用，所以我变得很感兴趣。”德克萨斯大学医学博士安德森癌症中心Uthealth生物医学研究生院的教师。“这就是发现很多头痛药物的方式；例如，我们认为偏头痛不是肌肉疾病，但是患有偏头痛的人出于整容原因而肉毒杆菌毒素，并发现它对偏头痛有所帮助。我们正在测试患者认为可能会有所帮助。”

簇头痛以循环模式称为群集时期，比分娩或肾结石更痛苦。最近的研究由Burish和其他一些研究人员表演。beplay苹果手机能用吗聚类的头痛通常在半夜唤醒一个人，头部一侧的眼睛内或周围的疼痛令人发指，一次攻击持续15分钟到三个小时。大多数攻击每天同时发生。

最初，参加Burish研究的人经历了筛查过程，其中包括访谈，检查，调查反应和血液工作。

The trial is seven weeks long. The first week of the trial is a baseline period, with no added medications. The second through fourth weeks are a double-blinded experimental period during which participants receive either high-dose vitamin D3 plus a multivitamin, or a placebo plus a multivitamin. During this time, participants fill out a survey and undergo blood testing.

第五周至第七周是一个开放标签时期，在此期间，所有参与者都接受高剂量维生素D3和多种维生素。

At the end of the seven-week period for each patient, Burish will measure changes in the average weekly frequency of cluster headache attacks among participants who received the high-dose vitamin D3 versus the placebo, along with other outcomes.

“Cluster headache is such an understudied disease, but it’s an extremely painful disorder,” Burish said, noting a previous study showing that more than 50% of individuals suffering from the attacks have had suicidal thoughts. “But based on previous research, vitamin D seems to block CGRP, a pain-signaling molecule that is commonly found in migraines and cluster headache, so we see a lot of promise with it.”

Overall, Burish is looking for roughly 220 study participants. To be eligible for enrollment, participants must be between 18 and 70 years old and have a diagnosis of either episodic or chronic cluster headache. They must also have predictable cluster periods that last at least six weeks, with a minimum of one attack daily.

参与者可能会在美国的任何地方都可以参加参加血液工作的实验室。有关研究的更多信息，请访问临床试验发布或致电713-486-7771致电RN Rebecca Martinez。

The study, expected to last through mid-2024, is being funded by the Erwin family.