在2020年，涉及可卡因的过量率飙升了近27％，德克萨斯大学健康科学中心的研究人员（休斯敦）的研究人员（beplay苹果手机能用吗Uthealth) hope that a clinical trial combining a medication approved for the treatment of Type 2 diabetes with cognitive behavioral therapy (CBT) can help prevent relapse in cocaine use disorder patients.

“This tragic rise in drug use has been attributed in part to uncertain and stressful times surrounding the COVID-19 pandemic,” saidJoy M. Schmitz，博士学位，该试验的联合主持调查员Scott D. Lane，，，，PhD, of the Center for Neurobehavioral Research on Addiction in the Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences at McGovern Medical School at UTHealth.

由美国国家药物滥用研究所提供的260万美元赠款（R01DA048026），II期，双盲，随机临床试验（刚刚开放供入学）正在寻找用于治疗2型糖尿病的吡格列酮。

The mechanism of action for pioglitazone is complex, but the medication includes anti-neuroinflammatory effects, making it a possible treatment for neurological conditions such as Parkinson’s disease, Alzheimer’s disease, brain trauma, and stroke. Similar to these brain diseases and injuries, studies of cocaine addiction conducted at UTHealth and elsewhere have shown that chronic cocaine use can have widespread neurotoxic effects, including in areas of the brain associated with cognitive function.

研究人员beplay苹果手机能用吗与休斯顿的正确步骤中心合作，为合格的参与者提供了两步治疗，这是从正确的步骤开始的短暂住院排毒开始，以帮助参与者实现可卡因的最初禁欲。

施密茨说：“对于多年使用的人来说，退出可卡因并不是一件小事。”“第二步是关于预防复发。”

最初的排毒后，参与者将接受12周的门诊治疗，包括单个CBT与吡格列酮或安慰剂组合。该研究将招收60名参与者。

“我们的想法是，吡格列酮将通过改善神经和认知功能来促进这些人的恢复过程，从而使患者从行为疗法中受益更多，”拥有教授Louis A. Faillace的Schmitz说。“ CBT与吡格列酮的结合预计将导致长期禁欲。”

该赠款基于莱恩（Lane）和施密茨（Schmitz）的先前beplay苹果手机能用吗研究，他们进行了首次人类神经影像学研究，以证明吡格列酮治疗如何改变可卡因使用障碍患者的脑白质完整性。他们的已发表的发现表明与安慰剂相比，吡格列酮在白质完整性方面取得了显着改善。此外，接受吡格列酮的患者对可卡因的渴望减少了。

“吡格列酮是一种修饰称为PPAR-GAMMA的脑受体系统的药物。它具有几种有希望的影响，包括减少炎症。通过这种机制，我们预计吡格列酮将有助于保护大脑免受可卡因使用造成的炎症损害。这种保护反过来应该有助于更有效的治疗结果。beplay苹果手机能用吗

还有很多的诊断and Interventional Imaging in McGovern Medical School are Khader Hasan, PhD, professor; and Ponnada Narayana, PhD, professor and holder of the Chair in Biomedical Engineering; from the Faillace Department of Psychiatry and Behavioral Sciences, Robert Suchting, PhD, assistant professor; and from the Department of Pediatrics, Charles Green, PhD, associate professor. Lane and Narayana are faculty members of The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences.

有关更多信息，请致电713-500-prug（3784）或访问：cnraclinic.com/2Step

Media Inquiries – 713-500-3030