GSBS教师Vbeplay苹果手机能用吗alentin Dragoi，PhD，Rochelle和Max Levit杰出教授的最新研究在神经科学中，报道了一个关于神经元如何在皮质回路中发出信号的新发现，已发表在该神经科学中的新发现。Proceedings of the National Academy of Sciences.

First author for the paper, “Brain state limits propagation of neural signals in laminar cortical circuits,” is Natasha Kharas, MD, PhD, GSBS alumna who worked in the Dragoi lab and neurosurgery resident at Cornell Medical College. Co-authors include GSBS alumni Ariana Andrei, PhD, and Sam Debes, PhD, postdoctoral research fellows in the Dragoi Lab.

Research for the paper is funded by a $1.8 million R01 grant from the National Institutes of Health received in 2022. The grant also funds Dragoi’s studies on sleep and its role in modulating information processing and cognitive function in animals.

Researchers injected a viral construct into the visual cortex to render neurons sensitive to blue light and hence increase their responses when an optical fiber emitted light. They subsequently monitored neural activity while animals performed a task or were sleeping for 20-30 minutes.

The study found that when animals are awake, but passive, or even when they performed a task, optogenetically-evoked electrical signals were strong, but remained local to the stimulated neural population. However, when animals were asleep, electrical signals spread out widely across the cortical circuit that they monitored. Because of this, Dragoi’s group discovered that during sleep, the coupling between neurons is strong, while they are only weakly coupled during the awake state.

此外，该研究表明，与高唤醒期相比，在beplay苹果手机能用吗被动清醒期间，信号在被动清醒期间更有效。

“Our work is important because it provides insight into the optimal brain state in which neurons communicate most effectively to propagate information across local circuits,” Dragoi said. “Surprisingly, this state is not the awake state when one would expect that signal flow would be most robust. Instead, neural communication is most efficient during sleep, but the exact role of this elevated neural trafficking is unknown.”

向前迈进，实验室将研究神经可塑性在清醒和睡眠期间如何变化。神经可塑性代表了单个细胞和种群适应环境变化的能力，并且被广泛认为是学习新技能的基础。

“Importantly, we will examine whether our findings can be used to improve therapeutics in humans with cortical dysfunction after neural injury or stroke,” Dragoi said.