Sarah Xuelian Huang博士，MB.B.S.，博士学位

Sarah Xuelian Huang博士，MB.B.S.，博士学位

干细胞与再生医学中心助理教授

电子邮件地址：xuelian.huang@uth.tmc.edu
Phone Number:713-500-2461
Room Number:SRB 630A

Narrative

Research interests

Realization of stem cell therapy in lung diseases relies on the successful generation of clinically applicable cell types. As a first, critical step in this direction, we have previously developed a step-wise differentiation strategy that directs human pluripotent stem cells (hPSCs) to become different types of upper and lower respiratory lung epithelial cells at large quantities. This differentiation platform was established based on advanced knowledge from animal developmental and genetic studies. It has been applied for lung development or disease studies by different research groups. However, for obtaining hPSC-derived lung epithelial cells with functionality and maturity suitable for clinical applications, we need to be able to understand lung developmental paradigm in greater details than currently possible. The main focus of our lab is to expand our knowledge on the mechanisms of lung lineage specification and tissue organization, and to use this knowledge for the development of innovativein vitrolung tissue models for studies of lung diseases and cell therapy. Currently, we are working on a model system for mapping the pathogen recognition patterns and the cellular and molecular responses of the lung epithelial cells to pathogen infection.

Education and training

黄博士MB.B.S收到了她。从西安交通University College of Medicine, Xi’an, China in 2000. She started to develop research interest in lung diseases when she joined the Master of Science program at Peking University Health Science Center, Beijing, China. She examined the inflammatory responses of rat alveolar macrophages to air pollution particulate matters collected in the urban area of Beijing. Dr. Huang received her PhD from Columbia University, New York, where she studied asbestos-induced responses in immune & inflammatory signaling of human small airway epithelial cells in the laboratory of Dr. Tom K. Hei from 2003 to 2009. Dr. Huang performed her postdoctoral training in Dr. Hans Snoeck’s Laboratory initially at Mount Sinai School of Medicine, New York, and later in Columbia University after Snoeck lab moved there. The main goal of Dr. Huang’s project was to establish a new model system for human lung disease studies. This new system was based on directed differentiation of hPSCs into specific organ cell types. Dr. Huang’s work was one of the first to rigorously and systemically demonstrate the generation of various lung and airway epithelial cell types directly from hPSCs with a particular enrichment in lower respiratory alveolar epithelial cells. Dr. Huang’s work further demonstrated the feasibility of this system for modeling infectious lung disease through collaboration with Dr. Jean-Laurent Casanova Lab at Rockefeller University. Utilizing the protocol, she developed, other research groups have successfully adapted the system for lung development or disease studies. In January 2017, Dr. Huang Joined the Center for Stem Cell and Regenerative Medicine (CSCRM) at the Brown Foundation Institute of Molecular Medicine (IMM) at UTHealth.

Selected Publications

  1. Ya-Wen Chen, Sarah X.L. Huang, Ana L.R.T. Carvalho, Siu-Hong Ho, Mohammad N. Islam, Stefano Volpi, Luigi D. Notarangelo, Michael Ciancanelli, Jean-Laurent Casanova, Jahar Bhattacharya, Alice F. Liang, Laura M. Palermo, Matteo Porotto, Anne Moscona & Hans-Willem Snoeck. A three-dimensional model of human lung development and disease from pluripotent stem cells.Nat Cell Biol.2017 May;19(5):542-549. doi: 10.1038/ncb3510. Epub 2017 Apr 24.
  2. Finn Hawkins，Philipp Kramer，Anjali Jacob，Ian Driver，Dylan C. Thomas，Katherine B. McCauley，Nicholas Skvir，Ana M. Crane，Anita A. Kurmann，Anthony N.哈利勒，莎拉X.L.Huang，Susan Guttentag，Jason R. Rock，John M. Shannon，Brian R. Davis和Darrell N. Kotton。源自多能干细胞的NKX2-1+/CD47+人类肺祖细胞的前瞻性分离和单细胞分析。临床调查杂志，2017年5月2日。PII：89950。DOI：10.1172/JCI89950。
  3. 约翰·奥尼尔（John O’Neill），布兰登（Brandon A.Huang，Ya-Wen Chen，Hans-Willem Snoeck，Matthew Bacchetta和Gordana Vunjak-Novakovic。交叉循环，用于体外支撑和肺的恢复。自然生物医学工程，2017，1，0037（2027）。
  4. Michael Ciancanelli，Sarah X.L.Huang，Priya Luthra，Hannah Garner，Yuval Itan，Stefano Volpi，Fabien G. Lafaille，CélineTrouillet，Mirco Schmolke，Elisabeth Israelsson，Melina Herman，Melina Herman，Tamar Hermesh，Tamar Hermesh，，，Tamar Hermesh，Lazaro Lorenzo，Randy A. Albrecht，Lawrence W. Leung，Satoshi Okada，Capucine Picard，Benedicte Ringuier，FrançoiseTroussier，Damien Chaussabel，Laurent Abel，Laurent Abel，Isabelle Pellier，Isabelle Pellier，Luigi D. Notarangelo，Notarangelo，Adarangelo，Adolfo basilfréabbasiler，基础，基础，基础，基础。Geissmann，Shen-Ying Zhang，Hans W. Snoeck和Jean-Laurent Casanova。传染病。损害的先天和内在的IFNα/β扩增构成了人类遗传IRF7缺乏症中威胁生命的流感。Science，2015年，4月24日； 348（6233）：448-53。doi：10.1126/science.aaa1578。EPUB 2015 3月26日。
  5. 莎拉X.L.Huang，Michael D Green，Ana Toste de Carvalho，Melanie Mumau，Ya-Wen Chen，Sunita L. D'Souza和Hans-Willem Snoeck。来自人多能干细胞的体外产生肺和气道祖细胞。Nature protocols.10，413–425，2015。在线发布，2015年2月5日（doi：10.1038/nprot.2015.023）。
  6. 莎拉X.L.Huang，Mohammad Naimul Islam，John O'Neill，Zheng Hu，Yong-Guang Yang，Ya-Wen Chen，Melanie Mumau，Michael D Green，Gordana Vunjak-Novakovic，Jahar Bhattacharya和Hans-Willem snoeck。从人多能干细胞中有效产生肺和气道上皮细胞。Nat Biotechnology，32，84–91，2014，第1期。（预先在线出版，12月1日英石, 2013. (doi:10.1038/nbt.2754).
  7. 迈克尔·格林（Michael D Green），莎拉（Sarah X.L.）黄，汉斯·威勒姆·斯诺克。呼吸系统的干细胞：从识别到分化为功能上皮。Bioessays. 2013 Mar;35(3):261-70. doi: 10.1002/bies.201200090. Epub 2012 Nov 22.